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A Retrospective Analysis of the Use of 3-Factor Prothrombin Complex Concentrates for Refractory Bleeding After Cardiopulmonary Bypass in Children Undergoing Heart Surgery: A Matched Case-Control Study

These results suggest the safety of 3FPCC when used for refractory bleeding after cardiopulmonary bypass in children undergoing congenital heart surgery.

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The Association between Cytokines and 365-Day Readmission or Mortality in Adult Cardiac Surgery

Pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10 may be postoperative markers of cardiac injury, and IL-6, specifically, shows promise in predicting readmission and mortality following cardiac surgery.

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Thrombin Generation and Antithrombin Activity in Infants Undergoing Cardiopulmonary Bypass—An Exploratory Study

In pediatric patients <10 kg undergoing cardiac surgery with CPB, thrombin generation and AT activity decline and do not recover completely after transfusion of platelets and cryoprecipitate.

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Low Tidal Volumes Are Associated With Slightly Improved Oxygenation in Patients Having Cardiac Surgery

Lower time-weighted average intraoperative tidal volumes were associated with a very modest improvement in postoperative oxygenation in patients having cardiac surgery.

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Comparison of Heat Monitoring-Based Myocardial Protection Strategy with Classic Myocardial Protection Method in Isolated Coronary Artery Bypass Surgery Patients

Our results show that there is no difference between temperature-based myocardial protection strategy with conventional intermittent cardioplegia delivery.

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Efficacy of Unilateral Cerebral Perfusion for Brain Protection in Aortic Arch Surgery

Unilateral cerebral perfusion performed in the described conditions is highly effective for cerebral protection in aortic arch surgery.

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Liraglutide for Perioperative Management of Hyperglycaemia in Cardiac Surgery Patients: a Multicentre Randomized Superiority Trial

Preoperative liraglutide, compared with placebo, reduces insulin requirements while improving perioperative glycaemic control during cardiac surgery.

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Sustained High-dose Thiamine Supplementation in High-risk Cardiac Patients Undergoing Cardiopulmonary Bypass: A Pilot Feasibility Study (The APPLY trial)

A double-blind trial of sustained high-dose intravenous thiamine supplementation in higher-risk cardiac surgery patients was feasible and appeared to be safe. However, such treatment did not demonstrate evidence of biological or physiological effects.

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Safety of Custodiol Cardioplegia: a Cohort Study in Patients Undergoing Cardiac Surgery with Elongated Aortic Cross-Clamp Time

Custodiol is a safe method of myocardial protection for patients who underwent mitral valve surgery with coronary artery bypass grafting in our hospital.

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Are Serum Potassium and Magnesium Levels Associated with Atrial Fibrillation After Cardiac Surgery?

Maintaining a serum potassium concentration ≥4.5 mmol/L after cardiac surgery may reduce the incidence of postoperative AF. Magnesium supplementation was associated with an increased risk of postoperative AF.

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Maximizing the Impact of Surgical Health Services Research The Methodology Toolbox

This series will help with research and eventually helps our profession and most of all, the patients we serve.

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Strategies to Minimize Intraoperative Blood Loss During Major Surgery

Reducing perioperative blood loss requires a multimodal and multidisciplinary approach. Although high‐quality evidence exists in certain areas, the overall evidence base for reducing intraoperative blood loss remains limited.

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Preoperative Intravenous Iron Before Cardiac Surgery: a Prospective Multicentre Feasibility Study

The development of an intravenous iron pathway is feasible but appears limited to selected high-risk cardiac patients in routine NHS practise. Although intravenous iron increased [Hb], there is a need for an appropriately powered clinical trial to assess the clinical effect of intravenous iron on patient-centred outcomes.

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TEG Platelet Mapping and Impedance Aggregometry to Predict Platelet Transfusion During Cardiopulmonary Bypass in Pediatric Patients

TEG-PM ADP may provide more clinically relevant information regarding platelet function compared to the MEIA at the ADP receptor in children requiring cardiopulmonary bypass.

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Effects of Milrinone on Renal Perfusion, Filtration and Oxygenation in Patients with Acute Heart Failure and Low Cardiac Output Early After Cardiac Surgery

In patients with acute heart failure after weaning from CPB, the milrinone-induced increase in cardiac output was accompanied by improved renal oxygenation.

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Vasoplegia During Cardiopulmonary Bypass: Current Literature and Rescue Therapy Options

Understanding the evidence for, dosing, and side effects of these agents is crucial for cardiac anesthesiologists when treating vasoplegia during CPB bypass.

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Use of Augmented Reality to Assist Teaching for Future Perfusionists in Extracorporeal Technology

Unlike other computing technologies, AR interfaces offer seamless interaction between the real and virtual worlds, a tangible interface metaphor, and a means for transitioning between real and virtual worlds. Here, we have shown our experiences of cost-effective AR technology for future perfusionists.

The Effect of Standardizing Autologous Prime Techniques in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass

The Effect of Standardizing Autologous Prime Techniques in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass

The application of an ST-AP protocol was effective in reducing hemodilution, which was associated within higher Hcts and lower postoperative transfusion rates.

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Does Standardizing Extracorporeal Circuit Design for Cardiopulmonary Bypass Affect Outcomes? Results from a National Perfusion Registry

Although small changes in the net prime volume and transfusion rates were seen with the standardization of ECCs, the primary benefit of this initiative was the increased familiarity and continuity of circuit design across sites.

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Net Prime Volume Is Associated with Increased Odds of Blood Transfusion

Our findings reinforce the importance of efforts to reduce the net CPB prime volume. Based on these findings and other supporting evidence, the net prime volume should be adopted as a national quality measure.

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Cryoglobulinemia: Caution for Patients Undergoing Cardiac Surgery

Keywords: Cardiopulmonary bypass, cryoglobulinemia, heart valve prosthesis implantation, hepatitis C, thoracic surgery, vasculitis.

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Real-Time Intraoperative Determination and Reporting of Cerebral Autoregulation State Using Near-Infrared Spectroscopy

We sought to determine the performance of the cotrending method by comparing its CA metrics to data derived from transcranial Doppler (TCD) methods.

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Heparin Sensitivity and Postoperative Blood Loss in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass

Postoperative blood loss is related to heparin sensitivity in patients undergoing cardiac surgery, and the moderately sensitive patients have the least postoperative bleeding.

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Application of Piezo-Based Measuring System for Evaluation of Nucleic Acid-Based Drugs Influencing the Coagulation

The obtained results showed that the established PIEZ is capable to dynamically measure the hemostasis status in whole blood and can be applied to analyze nucleic acid-based drugs influencing the coagulation.