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Heparin Dose and Point-of-Care Measurements of Hemostasis in Cardiac Surgery—Results of a Randomized Controlled Trial

Compared with a lower dose of heparin during CPB, a high dose of heparin had little effect on the point-of-care measurements of hemostasis, TEM, and MEA. Based on the similarity of platelet and coagulation activity assessments, the higher heparin dose does not appear to offer benefit during CPB.

Bill N Cover|Mission Checklist

Thrombin Generation and Bleeding in Cardiac Surgery: a Clinical Narrative Review

This narrative review discusses the role of thrombin generation in coagulation and bleeding in cardiac surgery, the laboratory methods for clinical detection of impaired thrombin generation, and the available hemostatic interventions that can be used to improve thrombin generation.

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Clotting Time Results Are Not Interchangeable Between EXTEM and FIBTEM on Rotational Thromboelastometry

CyD shortens the onset of TG and clot formation, resulting in shorter CTFIBTEM than CTEXTEM.

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Frequency and Outcomes of Elevated Perioperative Lactate Levels in Adult Congenital Heart Disease Patients Undergoing Cardiac Surgery

Currently there is insufficient evidence to use lactate levels as a predictor of outcomes in adult patients with congenital heart disease undergoing cardiac surgery.

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The Use of Extracorporeal Membrane Oxygenation in Human Immunodeficiency Virus–Positive Patients: a Review of a Multicenter Database

Survival among patients with human immunodeficiency virus infection who receive extracorporeal membrane oxygenation was less than 40%.

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Safety and Efficacy of a Novel Pneumatic-Driven ECMO Device

The pneumatically-driven ECMO device provides excellent safety and physiologic efficacy in a 7-day sheep experiment without visible clotting, hemolysis, or sustained reductions in fibrinogen or platelets.

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Mechanical Ventilation Management during Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome. An International Multicenter Prospective Cohort

Ultraprotective lung ventilation on ECMO was largely adopted across medium– to high–case volume ECMO centers. In contrast with previous observations, mechanical ventilation settings during ECMO did not impact patients’ prognosis in this context.

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The Right Ventricle after Cardiopulmonary Bypass: new Insights on its Adaptive Physiology

Post cardiopulmonary bypass (CPB) right ventricular (RV) dysfunction has been extensively described in cardiac surgery

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Vitamin D and Postoperative Delirium After Coronary Artery Bypass Grafting: A Prospective Cohort Study

Preoperative severe vitamin D deficiency was associated with the occurrence of delirium after coronary artery bypass grafting surgery.

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MHCA with SACP versus DHCA in Pediatric Aortic Arch Surgery: A Comparative Study

MHCA + SACP is associated with better short-term outcomes in children receiving aortic arch surgery under CPB.

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Contemporary Australian Priming Constituents for Adult Perfusion Centres: a Survey

Contemporary Australian priming practices show a marked level of conformity between units. Variation exists in the rationale for adding sodium bicarbonate, mannitol and albumin.

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Predisposing and Precipitating Factors Associated With Postoperative Delirium in Patients Undergoing Cardiac Surgery at a Veterans Affairs Medical Center: A Pilot Retrospective Analysis

These findings in VA patients generally are similar to those observed in the civilian population despite the differences between these cohorts.

The Effect of Restrictive Versus Liberal Transfusion Strategies on Longer-Term Outcomes After Cardiac Surgery: a Systematic Review and Meta-Analysis with Trial Sequential Analysis

The Effect of Restrictive Versus Liberal Transfusion Strategies on Longer-Term Outcomes After Cardiac Surgery: a Systematic Review and Meta-Analysis with Trial Sequential Analysis

In adult patients undergoing cardiac surgery, a restrictive transfusion strategy reduces RBC transfusion without impacting mortality rate or the incidence of other perioperative complications.

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Standards and Best Practice for Acute Normovolemic Hemodilution: Evidence-based Consensus Recommendations

The recommendations developed by this expert panel may help guide the management and inclusion of ANH as an evidence and consensus-based blood conservation modality.

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In Vitro Recovery of Sufentanil, Midazolam, Propofol, and Methylprednisolone in Pediatric Cardiopulmonary Bypass Systems

The present in vitro experiment with neonatal, infant, and pediatric CPB systems shows a variable recovery of routinely used drugs with significant differences between drugs, but not between system categories (with the exception of propofol).

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Perioperative Anemia Management as Part of PBM in Cardiac Surgery – A Narrative Updated Review

The World Health Organization has urged all Member States to implement PBM.

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Fetal Cardiac Interventions: Where Do We Stand?

Fetal cardiac intervention (FCI) is a novel and evolving technique that allows for in utero treatment of a subset of congenital heart disease.

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Neuroprotective Effect of Low Mean Arterial Pressure on Postoperative Cognitive Deficit Attenuated by Prolonged Coronary Artery Bypass Time: A Meta-Analysis

The neuroprotective effect of low MAP on POCD was attenuated by the prolonged CPB time.

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Effect and Safety of 4% Albumin in the Treatment of Cardiac Surgery Patients: Study Protocol for the Randomized, Double-Blind, Clinical ALBICS (ALBumin In Cardiac Surgery) Trial

The findings of this study will provide new evidence regarding efficacy and safety of albumin solution in adult patients undergoing cardiac surgery with CPB.

Bill N Cover|Mission Checklist

Cognitive Engineering to Improve Patient Safety and Outcomes in Cardiothoracic Surgery

Improved understanding of the cognitive basis of preventable medical errors offers the opportunity to develop new strategies to prevent and mitigate human errors in cardiothoracic surgery.

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Epiaortic Ultrasound to Prevent Stroke in Coronary Artery Bypass Grafting

When manipulation of the ascending aorta is planned, EAU is effective in guiding the surgical strategy to reduce the risk for embolic stroke in these patients.

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Hyperlactatemia during Cardiopulmonary Bypass: Risk Factors and Impact on Surgical Results with a Focus on the Long-Term Outcome

Correction of risk factors for hyperlactatemia, together with prompt detection and correction of this condition, may control complications and improve outcome.

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The Experience of Early Extubation After Paediatric Congenital Heart Surgery in a Chinese Hospital

Patients with early extubation had a lower reintubation rate and nasal continuous positive airway pressure rate, and a shorter length of stay in the ICU and hospital.

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Pulsatile Flow is not a Magic Bullet for Congenital Heart Surgery Patients during CPB Procedures

The objective of this editorial is to clarify common myths related to the effects of pulsatile flow on circuit optimization and vital organ recovery in congenital heart surgery patients undergoing CPB