Posts Tagged ‘Blood Management’
Sanibel Symposium 2021
The 10th annual Sanibel Symposium will be held on April 14-17th, 2021. Please be advised that the Sanibel Symposium will be fully online and webcast again next year.
Read MoreOutcomes of Cardiac Surgery in Jehovah’s Witness Patients: A Review.
The use of a bloodless protocol for Jehovah’s Witnesses does not appear to significantly impact upon clinical outcomes when compared to non-Witness patients, and it has even been suggested that a bloodless approach could provide advantages to all patients undergoing cardiac surgery. Larger cohorts and research across multiple centres into the long term outcomes of these patients is required.
Read MorePrompt Prediction of Fibrinogen Concentration During Cardiopulmonary Bypass: A Pilot Study
Our results indicate a strong correlation between fibrinogen activation and serum fibrinogen concentration. The maximum amplitude of activator f can estimate low fibrinogen concentration faster than traditional methods; this method quickly provides important information for anesthesia and hemostatic management in cardiac surgery.
Read MoreExposure–Response Relationship of Tranexamic Acid in Cardiac Surgery: A Model-based Meta-analysis
In cardiopulmonary bypass surgery, low-dose tranexamic acid seems to be an appropriate regimen for reducing bleeding outcomes. This meta-analysis has to be interpreted with caution because the results are observational and dependent on the lack of bias of the predicted tranexamic acid exposures and the quality of the included studies.
Read MoreIncidental Detection of Factor XII Deficiency Following Coronary Artery Bypass Grafting
In conclusion, fXII deficiency is a very rare disorder that is manifested by elevated aPTT and ACT values. Timely diagnosis, adequate perioperative coagulation monitoring, and postoperative prophylaxis with LMWH will minimize the occurrence of complications.
Read MoreAcute Normovolemic Hemodilution for A Patient with Secondary Polycythemia Undergoing Aortic Valve Replacement Due to Severe Aortic Stenosis – A Case Report
We estimate that patients with secondary polycythemia may benefit from acute normovolemic hemodilution to reduce their hematocrit levels while undergoing cardiac surgery using cardiopulmonary bypass. However, it is necessary to control the hematocrit level, since a significant decrease can cause side effects.
Read MoreProthrombin Complex Concentrate vs. Fresh Frozen Plasma in Adult Patients Undergoing Heart Surgery – A Pilot Randomised Controlled Trial (PROPHESY Trial)
Haemostatic tests have provided useful insight into the haemostatic changes following prothrombin complex concentrate or fresh frozen plasma administration. A definitive trial is needed to ascertain the benefits and safety for each.
Read MoreBlood Transfusion Threshold in Patients Receiving Extracorporeal Membrane Oxygenation Support for Cardiac and Respiratory Failure—A Systematic Review and Meta-Analysis
The present study did not resolve uncertainty as to transfusion management in ECMO, although several studies (most of them in VV ECMO) demonstrated that a restrictive threshold has acceptable outcomes in single-center cohorts.
Read MoreA Last Resort When There is No Blood: Experiences and Perceptions of Intraoperative Autotransfusion Among Medical Doctors Deployed to Resource-Limited Settings
The participants found that simple IAT is under-utilised in resource-limited settings. Missed opportunities to use IAT were mainly associated with armed conflict settings and obstetrical emergencies.
Read MoreManaging the Coagulopathy Associated with Cardiopulmonary Bypass.
While challenging, the effective management of CPB‐associated coagulopathy can significantly improve patient outcomes.
Read MoreNo Bad Blood — Surviving Severe Anemia Without Transfusion
Physicians who accept the challenges of learning how to treat patients safely and successfully without the traditional safety net of blood transfusion may experience a new level of confidence and expanded opportunities for providing quality care for all patients.
Read MoreUnit-To-Unit Variability in The Deformability of Red Blood Cells
The present study has demonstrated that storage duration is only one of the factors, and seemingly not even the major one, affecting the PRBCs functionality.
Read MoreSimple and Effective Blood Salvage Technique for Extracorporeal Membrane Oxygenation Circuit
We describe a simplified technique to salvage the blood in the ECMO circuit that requires no special equipment, is safe, and maximizes blood salvage.
Read MoreCombined Use of Rotational Thromboelastometry (Rotem) and Platelet Impedance Aggregometry (Multiplate Analyzer) in Cyanotic and Acyanotic Infants and Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass: Subgroup Analysis of a Randomized Clinical Trial
This study showed that Rotem, but not Multiplate results, were associated with platelet transfusion in pediatric cardiac surgery with no intake of platelet inhibitors. The usefulness of combining these tests in platelet transfusion decision-making needs to be evaluated in larger populations.
Read MoreImpact of Intraoperative Cell Salvage on Concentrations of Antibiotics Used for Surgical Prophylaxis
Studies measuring the impact of IOCS on perioperative antibiotic concentrations are warranted.
Read MoreEffect of Red Blood Cell Storage Duration on Major Postoperative Complications in Cardiac Surgery: A Randomized Trial
This clinical trial, which was stopped at its midpoint owing to enrollment constraints, supports neither the efficacy nor the futility of transfusing either younger or older RBC units.
Read MoreVenous or Arterial Samples for Activated Clotting Time Measurements: A Systematic Review
Sampling source should be kept consistent to facilitate effective haemostatic strategies. More research is needed regarding variability in vascular surgery and novel clot assessment techniques.
Read MoreCovid-19-Associated Coagulopathy: Biomarkers of Thrombin Generation and Fibrinolysis Leading the Outcome
Severe patterns of COVID-19 ARDS are characterized by a thrombin burst and the consequent coagulation activation. Mechanisms of fibrinolysis regulation appear unbalanced toward fibrinolysis inhibition. This pattern ameliorates in survivors, whereas it worsens in nonsurvivors.
Read MoreCytosorb® Hemoadsorption of Apixaban During Emergent Cardio-Pulmonary Bypass: A Case Report
Insertion of a CytoSorb® cartridge in the CPB was safe and associated with rapid correction of Apixaban-associated anticoagulation.
Read MorePerioperative Applications of Therapeutic Plasma Exchange in Cardiac Surgery: A Narrative Review
The review is based on published literature and the authors’ institutional experience with perioperative TPE in cardiac surgical patients.
Read MoreViscoelastic Testing in Pediatric Patients
This manuscript is intended to give a structured overview of what has been published on the use of viscoelastic testing to guide bleeding management in neonates and children.
Read MoreHemophilia: A Review of Perioperative Management for Cardiac Surgery
This article provides a narrative review and framework for the perioperative management of patients with hemophilia A and B undergoing cardiac surgery.
Read MorePlatelet Factor-4 Concentration in Adult Veno-Arterial ECMO Patients
Our data suggest that PF4 concentration is mildly elevated during VA ECMO compared to control plasma. Estimated PF4-heparin ratios were not optimal for HIT antibody formation. These data support epidemiologic studies where HIT incidence is low during VA ECMO.
Read MoreThe Effect of Levosimendan On Postoperative Bleeding and Blood Transfusion in Cardiac Surgical Patients: A PRISMA-Compliant Systematic Review and Meta-Analysis
This meta-analysis suggested that, peri-operative administration of LEVO was not associated with increased risks of post-operative bleeding and blood transfusion requirement in cardiac surgical patients.
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