New Technologies : CORMATRIX: Bio-Tissue Technology

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Editor’s Note:

This is a product I discovered while reading online @ the FB site “Gruppo dei Perfusionisti!!!” an I Italian on-line perfusion group.¬†

My frriend Emiliano Vitalini posted the link for the article- and I had seen an insert on it before- so thought I would explore it some more ūüôā

About CorMatrix ECM¬ģ Technology

Found in all humans and animals, extracellular matrix or ECM is the naturally-occurring bioscaffold that surrounds cells in almost all tissues and organ structures. It has both structural and functional roles, and while the composition of the ECM varies by tissue, it is generally composed of four major types of molecules:

CorMatrix ECM Technology is a unique extracellular matrix that combines the innate attributes of nature with the precision of science to help the heart heal itself. It is an acellular biomaterial that does not encapsulate when surgically implanted, but is gradually remodeled, leaving behind organized and healthy tissue. The body’s tissue begins remodeling at the surgical site while the ECM maintains the needed tissue support. When implanted, the ECM acts as a scaffold into which the patient’s cells migrate and integrate, stimulating the patient’s natural wound-healing mechanisms. As the patient’s cells become active, they lay down their own collagen, which matures over time to form strong and permanent tissue repair without leaving behind permanent foreign material. Because the ECM contains primarily collagen, the device is gradually replaced as the patient’s tissue gradually turns over in a natural state of self-renewal.

Product Insert:

Repair of intracardiac tissue can be very difficult; it is needed to repair damaged cardiac structures or during procedures such as valve repair when the prosthetic valve available does not fit properly.

Until recently the repair and regrowth of cardiac tissue was thought not to occur and was regarded as a ‚Äúterminally differentiated‚ÄĚ tissue. This concept was challenged with the first report of implanted extracellular matrix regenerating right ventricular and right atrial muscle in 1996. Click here for the 1996 SIS Purdue Symposia Abstract.

CorMatrix ECM is ideal for intracardiac surgery based on its ability to remodel tissue. In cases such as atrial septal defect repair, CorMatrix ECM can effectively close a hole and generate new, healthy tissue in lieu of using objects such as nitinol plugs or synthetic patches. Because the tissue is remodeled, there is no foreign material left behind as is the case with more traditional repair materials.

The ECM composition provides the right environment for native cells to be recruited to the area of repair. Over time the ECM is remodeled and resorbed as new tissue develops. CorMatrix ECM is routinely used for:

Septal Repair Case Report
Institution: St. Francis Heart Center, Indianapolis, Indiana
Surgeon: Marc Gerdisch, MD