Cryoprecipitate contains 2 or more times the concentration of fibrinogen contained in plasma as well as increased levels of factor V and factor VIII. Each unit however, contains only 50 ml, thus conceivably requiring several units of cryoprecipitate to be administered in order to achieve target ranges (>150 mg/dl) for depleted fibrinogen levels. This represents exposure to multiple donors and implies an increased risk to the recipient.
Woodman RC, Harker LA. Bleeding Complications Associated with Cardiopulmonary Bypass. Blood. 1990;76:1680-97,
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