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Commentary: Do-it-yourself Cell Salvage

The cause of complications observed with increased cell salvage is likely to remain enigmatic.


Provision of ECPR during COVID-19: Evidence, Equity, and Ethical Dilemmas

The logistics of patient selection, expedient cannulation, healthcare worker safety, and post-resuscitation care must be weighed against the ethical considerations.


Predictors and Outcomes of Ischemic Stroke After Cardiac Surgery

Stroke is a devastating complication after cardiac surgery that increases operative morbidity and mortality. Stroke with large vessel occlusion was associated with worse survival. However, early intervention did not impart a survival benefit.


Perioperative Management for Patients with von Willebrand Disease: Defining the Optimal Approach

This review provides an overview of the current evidence for the surgical management of patients with VWD and, summarises the optimal treatment approach during the perioperative period

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COVID-19: Myocardial Injury in Survivors

In summary, myocardial injury is common in hospitalized COVID-19 patients and not exclusive to those with ACS or PE. In this single-centre, single-timepoint convalescent study, myocardial injury was associated with cardiac abnormalities detected by CMR where troponin elevation is unexplained even when cardiac function is normal.

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A European Consensus Statement on The Use of Four-Factor Prothrombin Complex Concentrate for Cardiac and Non-Cardiac Surgical Patients

Tissue‐factor‐activated, factor VII‐dependent and heparin insensitive point‐of‐care tests may be used for peri‐operative monitoring and guiding of prothrombin complex concentrate therapy.


Therapeutic Potential of Fibrinogen Γ-Chain Peptide-Coated, ADP-Encapsulated Liposomes as A Haemostatic Adjuvant for Post-Cardiopulmonary Bypass Coagulopathy

These findings suggest that H12-ADP-liposomes could help effectively and safely consolidate platelet haemostasis in post-CPB coagulopathy and may have potential for reducing bleeding complications after cardiovascular surgery with CPB.


Multiple Electrode Aggregometry After Cardiopulmonary Bypass to Assess Platelet (Dys)-Function and Transfusion Threshold: A Concordance Study

The application of new Multiplate analyzer technologies, like the ADP test, have the potential to reduce platelet transfusion rates in cardiac surgery patients compared with the use of platelet counts alone; this point-of-care test may constitute an important strategy to help spare the use of allogeneic blood products. Additional studies are needed to confirm this trend and establish the best cutoff values to apply.


Simulation-Based Training of Critical Events During Cardiopulmonary Bypass: Importance of A Critical Events Checklist

Evaluation of critical events during simulated cardiopulmonary bypass shows that the scenario is realistic and relevant for clinical practice. Integrating a critical events checklist improves the probability of correct decision-making and shortens the correct decision time.


Intravenous Iron Therapy for Patients with Preoperative Iron Deficiency or Anaemia Undergoing Cardiac Surgery Reduces Blood Transfusions: A Systematic Review and Meta-Analysis

This meta-analysis suggests that IV iron improves postoperative morbidity in adult cardiac surgery patients with preoperative anaemia or iron deficiency. A large, rigorous, placebo-controlled, double-blinded, multicentre trial is needed to clarify the role of IV iron in this patient population.

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Therapeutic Plasma Exchange: A potential Management Strategy for Critically Ill COVID-19 Patients

Herein, we briefly discuss some of the various approaches currently being investigated for the treatment of SARS-CoV-2 with a focus on potential benefits of TPE for selected critically ill patients.


Effects of Cardiac Surgery and Salvaged Blood Transfusion on Coagulation Function Assessed by Thromboelastometry

Salvaged blood transfusion of more than 18.5% whole blood volume may impair coagulation function particularly in patients with lower FIBTEM-MCF before and after cardiac surgery.


p-Values and Their Unintended Consequences

We provide a suggested course of action, for both journal editors and readers, to address this issue.


Comparison of Postoperative Cognitive Decline in Patients Undergoing Conventional Vs Miniaturized Cardiopulmonary Bypass: A Randomized, Controlled Trial

This study shows that the MCPB was not superior to CCPB with cell salvage and biocompatible tubing with regard to the neurocognitive outcomes measured by the RBANS.


Evaluation of Arterial Stiffness in Cardiac Surgical Patients Using Applanation Tonometry

Cardiac surgery was associated with an improvement in arterial stiffness, A-V coupling, and myocardial contractility as assessed using applanation tonometry. The results suggest, however, a transient imbalance between myocardial oxygen supply and demand in the immediate postoperative period.


Development of A Real-Time Blood Damage Monitoring Device for Cardiopulmonary Bypass System Using Near-Infrared Spectroscopy

The results demonstrate the clinical potential of a real-time, low-cost, and reliable blood damage monitoring device to improve the safety of CPB operation.


The Long-Term Impact of Peripheral Cannulation for Redo Cardiac Surgery

This is the first study reporting the long‐term impact of peripheral cannulation for redo cardiac surgery after excluding patients with operative mortality. These data suggest that central cannulation may to be the preferred approach to redo cardiac surgery whenever safe and possible.


Association Between Lactates, Blood Glucose, and Systemic Oxygen Delivery in Children After Cardiopulmonary Bypass

In children after cardiopulmonary bypass, lactates are not correlated with higher oxygen extraction, but are correlated with hyperglycemia, at both 4 and 12 h after PICU admission. Future research is warranted to better define this relationship.


The Role of Entropy Monitoring in Reducing Propofol Requirements During Open Heart Surgeries. A Prospective Randomized Study

Entropy monitoring significantly reduced the dose of propofol required for induction of anesthesia and maintained hemodynamic stability compared to the conventional clinical monitoring during CABG surgeries.


Factors Influencing Activated Clotting Time Following Heparin Administration for the Initiation of Cardiopulmonary Bypass

Old age, heart failure, and lower platelet counts affected heparin activity. The dose of heparin should be considered in those patients to reach the target ACT.


Acute Oxygenator Occlusion in Two Cases of Polycythemia Vera: Bailout Strategies

We report two cases of acute and severe oxygenator failure during cardiopulmonary bypass and present valid exit scenarios.

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The Blood Protective Effect of Autologous Platelet Separation in Aortic Dissection

The intraoperative auto transfusion of platelets significantly reduced the volume of allogeneic platelet transfusion after the operation for aortic dissection, which has a significant blood protective effect.


Body Mass Index as A Tool for Optimizing Surgical Care in Coronary Artery Bypass Grafting Through Understanding Risks of Specific Complications.

In patients undergoing coronary artery bypass grafting, low and high BMI were risk factors of mortality associated with different types of morbidities, which may warrant tailored preventive approaches.


Oxygenator Impact on Voriconazole in Extracorporeal Membrane Oxygenation Circuits

Further evaluations with multiple dose in vitro and in vivo investigations are needed before specific voriconazole dosing recommendations can be made for clinical application with extracorporeal membrane oxygenation.