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Machine Learning Models with Preoperative Risk Factors and Intraoperative Hypotension Parameters Predict Mortality After Cardiac Surgery

Machine learning models incorporating intraoperative adverse factors might offer better predictive ability for risk stratification and triaging of patients after cardiac surgery.


Decrease in Serum Alkaline Phosphatase and Prognostic Relevance in Adult Cardiopulmonary Bypass

Increased perioperative AP loss is associated with adverse early outcome. Prospective trials are needed to determine whether this effect can be counteracted by perioperative AP supplementation.

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Normoxic Management of Cardiopulmonary Bypass Reduces Myocardial Oxidative Stress in Adult Patients Undergoing Coronary Artery Bypass Graft Surgery

Normoxic cardiopulmonary bypass is associated with reduced myocardial oxidative stress compared to hyperoxic cardiopulmonary bypass in adult coronary artery bypass patients.


Acute Isotonic Hyponatremia After Single Dose Histidine-Tryptophan-Ketoglutarate Cardioplegia: An Observational Study

Administration of histidine-tryptophan-ketoglutarate cardioplegia during cardiac surgery leads to acute moderate to severe isotonic hyponatremia, which resolves spontaneously in the first 18 hours perioperatively. Correction with hypertonic saline is not necessary.


Right Watershed Cerebral Infarction Following Neck Cannulation for Veno-Arterial Extracorporeal Membrane Oxygenation in Pediatric Septic Shock: A Case Series

The risk of ipsilateral watershed injury should be considered before cervical cannulation, notably in the context of sepsis.


Evidence-Based Translational Research Approach May Help to Select the Best Femoral Arterial Cannula for Adolescent/Adult Extracorporeal Life Support Population

The objective of this translational study is to evaluate eight femoral arterial cannulae (Medtronic and Maquet, 15 Fr, 17 Fr and 19 Fr compared to Medos: 16 Fr and 18 Fr) using an adolescent/adult extracorporeal life support (ECLS) circuitry.


Hyperoxia During Cardiopulmonary Bypass Does Not Increase Respiratory or Neurological Complications: A Post Hoc Analysis of The CARDIOX Study

Based on this post hoc analysis of the CARDIOX study, hyperoxia during CPB did not increase neurological or pulmonary complications. Controlled studies with a larger sample size are required to better address this specific issue.


Determinants of Neurological Outcome in Neonates with Congenital Heart Disease Following Heart Surgery

For HLHS and d-TGA patients, duration of mechanical ventilation and DHCA are associated with adverse neurologic outcome. Neonatal brain MRI commonly demonstrates acquired brain injuries, but the clinical impact of these abnormalities are not often seen before 2 years of age.


Perioperative Management of Hemophilia A Patients Undergoing Cardiac Surgery: A Literature Review of Published Cases

Execution of a perioperative management strategy with a multidisciplinary approach, a thorough factor replacement protocol, and careful monitoring of factor levels facilitate an optimal outcome for HA patients undergoing cardiac surgery.


Investigation of the Effect of Pulsatile and Nonpulsatile Flow on Kidney in Coronary Surgery With NIRS

fNIRS is being used to track cerebral functions. During operation, it also provides a correct observation for blood feeding of somatic organs, such as the kidneys, but it requires more clinical study to be accepted as routine.


Influence of Hypoxic and Hyperoxic Preconditioning on Endothelial Function in a Model of Myocardial Ischemia-Reperfusion Injury with Cardiopulmonary Bypass (Experimental Study)

Hypoxic-hyperoxic preconditioning helps to maintain the balance of nitric oxide metabolites, reduces endothelin-1 hyperproduction, and enforces organ protection.


Effect of Goal-directed Hemodynamic Therapy in Postcardiac Surgery Patients

Early goal-directed therapy reduces the postoperative ventilatory period, frequency of changes in inotropes, and incidence of AKI.


Building A Patient Blood Management Program in A Large-Volume Tertiary Hospital Setting: Problems and Solutions

In this review, we aimed to share previous experiences and indicate current problems with solutions which would ensure the implementation of a PBM protocol in our hospital that can be also a guide for similar large-volume tertiary hospitals.


Latent Trajectories of Fluid Balance Are Associated With Outcomes in Cardiac and Aortic Surgery

A progressively positive fluid balance is associated with AKI and de novo dialysis in patients undergoing cardiac or aortic surgery.

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Impact of Brain Protection Strategies on Mortality and Stroke in Patients Undergoing Aortic Arch Repair with Hypothermic Circulatory Arrest: Evidence from The Canadian Thoracic Aortic Collaborative

Antegrade cerebral perfusion and nadir temperature ≥24°C during HCA for aortic arch repair are predictors of improved survival and neurological outcomes.


Impact of Patient Blood Management Guidelines on Blood Transfusions and Patient Outcomes During Cardiac Surgery

Following the publication of the guidelines, there was a measurable reduction in perioperative blood transfusions in cardiac surgery with an associated reduction in hospital length of stay but no detectable differences in other patient outcomes.


The Use of Automated Pupillometry To Assess Cerebral Autoregulation: A Retrospective Study

Automated pupillometry cannot predict CAR indices such as Mxa in a heterogeneous population of critically ill patients.


Role of Extracorporeal Membrane Oxygenation In COVID-19: A Systematic Review

Our study highlights the paucity of evidence and the need for further data to consolidate the efficacy of ECMO in improving patient outcomes.


Myocardial Protection in Cardiac Surgery: How Limited Are the Options? A Comprehensive Literature Review

We provide a comprehensive and comparative overview of the effectiveness of each technique in achieving optimal cardioprotection and propose novel techniques for optimising myocardial protection in the future.

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Sulfated Polysaccharides Effectively Inhibit SARS-Cov-2 In Vitro

To this end, we suggest that treatment of fucoidans, nebulized heparin, or possibly TriS-heparin in combination with or without current antiviral therapies, should be assessed first in human primary epithelial cells and then in human patients suffering from COVID-19.


Nitric Oxide Delivery During Cardiopulmonary Bypass Reduces Acute Kidney Injury: A Randomized Trial

NO administration in patients at moderate risk of renal complications undergoing elective cardiac surgery with CPB was associated with a lower incidence of AKI.


A Better Predictor of Acute Kidney Injury After Cardiac Surgery: The Largest Area Under the Curve Below the Oxygen Delivery Threshold During Cardiopulmonary Bypass

These data suggest that a high AUC below the  is an important independent risk factor for AKI after cardiopulmonary bypass, which could be considered for risk prediction models of AKI.

Approach to Acute Cardiovascular Complications in COVID-19 Infection

Approach to Acute Cardiovascular Complications in COVID-19 Infection

This review discusses the presentation and management of patients with severe cardiac complications of COVID-19 disease, with an emphasis on a Heart-Lung team approach in patient management.


Extensive Cell Salvage and Postoperative Outcomes Following Thoracoabdominal and Descending Aortic Repair

Increased salvaged cell units were associated with adverse postoperative outcomes after D/TAAA repairs. Risk of renal failure and mortality increased proportionally to the salvaged cell units.