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The Impact of Intraoperative Patient Blood Management on Quality Development in Cardiac Surgery

Real-time laboratory recommendations achieved a high acceptance rate early after initiation. Improvement of clinical outcome by intraoperative PBM adds to the optimized surgical care. However, the corridor between hemostatic optimization and thromboembolic risk may be narrow.

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Oxygen and Carbon Dioxide Levels in Patients after Cardiac Arrest

There was no association between exposure to various levels of PaO 2 and PaCO 2 and neurological outcome after cardiac arrest.

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Sonographic Muscle Mass Assessment in Patients After Cardiac Surgery

Skeletal quadriceps muscle thickness assessed by ultrasound shows a trend to a decrease in patients after cardiac surgery post-ICU admission and is associated with prolonged duration of MV and ICU length of stay.

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Modulating the Bioactivity of Nitric Oxide as a Therapeutic Strategy in Cardiac Surgery

Perspectives for modulation of endothelial function using NO-mediated mechanisms are discussed. Some of these strategies may provide important therapeutic benefits for human cardiovascular interventions.

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Desflurane and Sevoflurane Concentrations in Blood Passing Through the Oxygenator During Cardiopulmonary Bypass: A Randomized Prospective Pilot Study

Our results demonstrated that the blood concentrations of desflurane and sevoflurane passing through oxygenators used during CPB were similar to those in the human lung control.

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Incidence of Ischemic Optic Neuropathy After Cardiopulmonary Bypass: 20-Year Experience

Practice improvements (eg, transition to membrane oxygenators, blood transfusion guidelines, less- invasive surgical options for high-risk patients) during the time between the authors’ studies likely affected the incidence reduction.

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Blood Pressure and Brain Injury in Cardiac Surgery: A Secondary Analysis of A Randomized Trial

A higher mean arterial pressure during CPB was associated with signs of impaired cerebral metabolism, though not at the predefined significance level of 0.01. No significant association was found between metabolite ratio changes and neuroradiological pathology or change in cognitive function.

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Use of Factor VIIa and Anti-inhibitor Coagulant Complex in Pediatric Cardiac Surgery Patients

Both rFVIIa and FEIBA reduced blood product usage in pediatric patients following cardiac procedures.

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The Use of Hemostatic Blood Products in Children Following Cardiopulmonary Bypass and Associated Outcomes

Larger studies should be performed to determine the hemostatic efficacy of these products, as well as to clarify associated morbidities, in order to inform proper blood management.

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Fibrinolysis and the Influence of Tranexamic Acid Dosing in Cardiac Surgery

The assessment of the fibrinolytic status may have the potential to facilitate dose-adjusted antifibrinolytic therapy in the future.

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Intraoperative Hemoadsorption in Patients With Native Mitral Valve Infective Endocarditis

These data suggest that intraoperative hemoadsorption may improve surgical outcome in patients with mitral valve endocarditis.

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Risk Factors for Complete Recovery of Adults After Weaning from Veno-Venous Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Failure: An Analysis from Adult Patients in The Extracorporeal Life Support Organization Registry

Complete recovery after veno-venous ECMO support is associated with the patient’s baseline condition, ECMO duration, and ECMO-related complications. Respiratory ECMO should aim to increase both the survival and the quality of life after weaning from ECMO.

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Near-Infrared Spectroscopy in Adult Circulatory Shock: A Systematic Review

Near-infrared spectroscopy-derived StO2 can predict mortality in circulatory shock, but high-quality data on the impact of NIRS monitoring are lacking.

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Mobilizing Carbon Dioxide Stores: An Experimental Study

CO2 from body stores can be mobilized over 48 hours without reaching a steady state. This provides a physiological rationale for intermittent ECCO2R in chronically hypercapnic patients.

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ECCO2R Therapy in the ICU: Consensus of A European Round Table Meeting

Insights from this group of experienced physicians suggest that ECCO2R therapy may be an effective supportive treatment for adults with ARDS or ae-COPD. Further evidence from randomised clinical trials and/or high-quality prospective studies is needed to better guide decision making.

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Sickle Cell-Related Complications in Patients Undergoing Cardiopulmonary Bypass

In this cohort of patients, older age, longer CPB times, lower median temperature, and the utilization of deep hypothermic circulatory arrest appear to play an important role in the development of complications.

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Extracorporeal Blood Purification Treatment Options For COVID-19: The Role of Immunoadsorption

Several extracorporeal blood purification therapies are now available, and most of them target endotoxins and/or the cytokines and aim improving the immune response. For this purpose, plasmapheresis and immunoadsorption may be an important adjunctive treatment option to manage the complications caused by cytokine storm in critically ill patients with COVID-19.

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Thromboelastography Profiles of Critically Ill Patients With Coronavirus Disease 2019

A large proportion of critically ill patients with coronavirus disease 2019 have hypercoagulable thromboelastography profiles with additional derangements related to fibrinogen and platelet function. As the majority of patients have an elevated thromboelastography maximum amplitude, a follow-up study evaluating platelet aggregation would be instructive.

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A Pharmacokinetic and Pharmacodynamic Investigation of an ε-Aminocaproic Acid Regimen Designed for Cardiac Surgery with Cardiopulmonary Bypass

This regimen provided maximum EACA concentrations near the time of protamine administration, with a total perioperative dose of 15 g.

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Blood Management in A Patient with Anti-Oka Antibody Who Underwent Cardiac Surgery Using Cardiopulmonary Bypass: A Case Report

Multidisciplinary intraoperative blood management in a patient with anti-Oka antibody facilitated successful cardiac surgery using CPB, along with effective use of limited blood products.

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Efficacy of Glyceryl Trinitrate (GTN) To Facilitate the Rewarming Process During Cardiopulmonary Bypass

Higher dose GTN infusion during rewarming on CPB does not improve peripheral-core temperature gradient post operatively and has no effect on post-operative lactate concentrations.

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Effect of Antithrombin in Fresh Frozen Plasma on Hemostasis After Cardiopulmonary Bypass Surgery

Fresh frozen plasma administration increased antithrombin activity and caused activated clotting time prolongation, but then increased clotting ability. Thus, testing by rotational thromboelastometry after cardiopulmonary bypass could be valuable in the detection of comprehensive clotting ability.

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Conventional Versus Minimally Invasive Extracorporeal Circulation In Patients Undergoing Cardiac Surgery: Protocol For A Randomised Controlled Trial (COMICS)

The trial is feasible but criteria for progressing to a full trial were not met on time. The Trial Steering and Data Monitoring Committees have recommended that the trial should currently continue.

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Continuous Cerebral and Myocardial Selective Perfusion in Neonatal Aortic Arch Surgery

CCMSP is a safe and reproducible strategy for cerebral, myocardial and visceral protection in neonatal aortic arch repair, with or without VSD closure, resulting in low complication and mortality.