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Street Ecmo 3

ECMO as a Platform for Rapid Ammonia Removal in a Neonate With Multienzyme Urea Cycle Disorder

This case will add to the existing scant literature supporting the use of ECMO as a platform for rapid removal of serum ammonia.

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Deep Hypothermic Circulatory Arrest Activates Neural Precursor Cells in Neonatal Brain

Neonatal piglet ACP at 18°C or 25°C provides adequate protection from increased brain cellular apoptosis. In contrast to ACP however, DHCA induces brain Nestin expression, indicating activation of neural progenitor cells and the potential of altering neonatal neurodevelopmental progression.


Neck Cannulation for Bypass in Redo Sternotomy in Children and Adults with Congenital Heart Disease

Cannulation of the right neck vessels for peripheral cardiopulmonary bypass prior to high-risk redo sternotomy in children and adults with congenital heart disease is a safe and effective strategy.

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COVID-19 FAQ’s in Pediatric Cardiac Surgery

The purpose of this review is to succinctly summarize frequently asked questions related to COVID-19 as it relates to children with congenital heart disease.

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COVID-19: Crisis Management in Congenital Heart Surgery

The safety of our patients, healthcare providers, and our communities is our chief concern. This document is not meant to be a guideline but is designed to provide guidance for decision-making as we face unparalleled challenges related to congenital cardiac surgery care during this pandemic.


Are Blood Products Routinely Required in Pediatric Heart Surgery?

The majority of children with a BW > 8.5 kg required no blood products and those with a BW ≤ 8.5 kg required only 1 unit of blood, to prime the cardiopulmonary bypass circuit.


The Utility of Albumin Level as a Marker of Postoperative Course in Infants Undergoing Repair of Congenital Heart Disease

In summary, we found that preoperative and POD#2 albumin levels predicted prolonged and complicated postoperative course.


Cell-Cycle Arrest Biomarkers Usefulness for Cardiac Surgery-Related Acute Kidney Injury in Neonates and Infants

These findings question the usefulness of (TIMP-1) × (IGFBP-7) for the prediction of cardiac surgery-related acute kidney injury in neonates and infants when measured within 3 hours of cardiopulmonary bypass.

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Frequency and Outcomes of Elevated Perioperative Lactate Levels in Adult Congenital Heart Disease Patients Undergoing Cardiac Surgery

Currently there is insufficient evidence to use lactate levels as a predictor of outcomes in adult patients with congenital heart disease undergoing cardiac surgery.

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In Vitro Recovery of Sufentanil, Midazolam, Propofol, and Methylprednisolone in Pediatric Cardiopulmonary Bypass Systems

The present in vitro experiment with neonatal, infant, and pediatric CPB systems shows a variable recovery of routinely used drugs with significant differences between drugs, but not between system categories (with the exception of propofol).


Fetal Cardiac Interventions: Where Do We Stand?

Fetal cardiac intervention (FCI) is a novel and evolving technique that allows for in utero treatment of a subset of congenital heart disease.


The Experience of Early Extubation After Paediatric Congenital Heart Surgery in a Chinese Hospital

Patients with early extubation had a lower reintubation rate and nasal continuous positive airway pressure rate, and a shorter length of stay in the ICU and hospital.


Pulsatile Flow is not a Magic Bullet for Congenital Heart Surgery Patients during CPB Procedures

The objective of this editorial is to clarify common myths related to the effects of pulsatile flow on circuit optimization and vital organ recovery in congenital heart surgery patients undergoing CPB

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Anticoagulation in Neonatal ECMO: An Enigma Despite a Lot of Effort!

This review provides an overview of hemostatic alterations, anticoagulation, monitoring and management, novel anticoagulant use, and circuit modifications for neonatal ECMO. Future considerations are also presented.


Impact of Delayed Systemic Heparinization on Postoperative Bleeding and Thromboembolism During Post-Cardiotomy Extracorporeal Membrane Oxygenation in Neonates

In this retrospective analysis, the results of delayed systemic heparinization in neonatal post-cardiotomy extracorporeal membrane oxygenation could lead one to conclude that this routine is safe and favorable with low risk for thromboembolic events, reduced postoperative hemorrhage, and reduced blood product utilization.


Lower Limit of Adequate Oxygen Delivery for the Maintenance of Aerobic Metabolism During Cardiopulmonary Bypass in Neonates

It was found that 340 ml min−1 m−2 is likely to represent the lowest suitable Ḋo2 required in neonates to maintain aerobic metabolism during normothermic CPB.


Use of Extracorporeal Membrane Oxygenation in Postcardiotomy Pediatric Patients: Parameters Affecting Survival

Parameters affecting mortality after extracorporeal membrane oxygenation support in pediatric postcardiotomy patient group were the presence of a syndrome, multiple runs of extracorporeal membrane oxygenation, and single-ventricular physiology.

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White Matter Brain Development after Exposure to Circulating Cell-Free Hemoglobin and Hyperoxia in a Rat Pup Model

In our model, exposure to circulatory cell-free Hb, with or without concomitant hyperoxia, did not significantly alter brain white matter development.


Selective Lower Body Perfusion During Aortic Arch Surgery in Neonates and Small Children

These findings show that a sufficient lower body perfusion through an arterial sheath placed in the femoral artery for aortic arch reconstruction can be achieved.


A Retrospective Analysis of the Use of 3-Factor Prothrombin Complex Concentrates for Refractory Bleeding After Cardiopulmonary Bypass in Children Undergoing Heart Surgery: A Matched Case-Control Study

These results suggest the safety of 3FPCC when used for refractory bleeding after cardiopulmonary bypass in children undergoing congenital heart surgery.

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Thrombin Generation and Antithrombin Activity in Infants Undergoing Cardiopulmonary Bypass—An Exploratory Study

In pediatric patients <10 kg undergoing cardiac surgery with CPB, thrombin generation and AT activity decline and do not recover completely after transfusion of platelets and cryoprecipitate.


Glial Fibrillary Acid Protein and Cerebral Oxygenation in Neonates Undergoing Cardiac Surgery

The potential value as a biomarker for cerebral injury after neonatal cardiac surgery warrants further investigation; in particular, the association with neurodevelopmental outcome needs to be determined.


Myocardial Protection in the Arterial Switch Operation: Custodiol Versus Cold Blood Cardioplegia

The optimal myocardial protective solution in the neonatal arterial switch operation remains controversial.


Single Ventricle Physiology Patients and Coagulation Abnormalities: Is There a Relationship With Hemodynamic Data and Postoperative Course? A Pilot Study

Abnormalities in coagulation parameters are common in SV patients. Coagulation abnormalities constitute a preoperative risk factor and affect postoperative course.