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VAD|Nov 20|Paul

Developments in Pediatric Ventricular Assist Device Support

Mechanical support devices have revolutionized the management of circulatory failure.

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Effect of Blood Flow on Platelets, Leukocytes, and Extracellular Vesicles in Thrombosis of Simulated Neonatal Extracorporeal Circulation

Extracorporeal membrane oxygenation (ECMO) has frequent and sometimes lethal thrombotic complications.

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Structured Review of Post-cardiotomy Extracorporeal Membrane Oxygenation: Part 2—Pediatric Patients

This report, aims to present a comprehensive overview of the available literature informing patient selection, ECMO management, and in-hospital and early post-discharge outcomes in pediatric patients treated with ECMO for post-cardiotomy cardiorespiratory failure.

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Early and Long-Term Outcomes Comparing Neonates, Infants, and Preadolescents Requiring Extracorporeal Membrane Oxygenation for Heart Failure

Veno-arterial extracorporeal membrane oxygenation is a lifesaving therapeutic chance for pediatric patients in the setting of either failure to wean from cardiopulmonary bypass or failed resuscitation from cardiac arrest.

Bill N Cover|Mission Checklist

Epidemiology of Acute Kidney Injury Among Paediatric Patients After Repair of Anomalous Origin of the Left Coronary Artery From the Pulmonary Artery

Acute kidney injury (AKI) is a prevalent complication after the surgical repair of paediatric cardiac defects and is associated with poor outcomes.

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Peak Creatinine, Cardiopulmonary Bypass and Mortality After Stage One Single-ventricle Reconstruction

It is important to identify therapies which minimise complications associated with prolonged cardiopulmonary bypass duration in high risk populations.

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Custodiol cardioplegia Solution Compared to Cold Blood cardioplegia in Pediatric Cardiac Surgery: a Single-institution Experience

Single-dose Custodiol is as safe as blood cardioplegia for myocardial protection in congenital cardiac surgery for the cross-clamp times evaluated in this study.

Bill N Cover|Mission Checklist

Impact of Cardiopulmonary Bypass and Aorta Cross Clamp Time on the Length of Mechanical Ventilation after Cardiac Surgery among Children: A Saudi Arabian Experience

According to our results, CPB and ACC time are not associated with PMV or prolonged hospital LOS.

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Alkaline Phosphatase Treatment of Acute Kidney Injury in an Infant Piglet Model of Cardiopulmonary Bypass with Deep Hypothermic Circulatory Arrest

Acute kidney injury (AKI) is associated with prolonged hospitalization and mortality following infant cardiac surgery, but therapeutic options are limited.

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Acquired von Willebrand Syndrome in Pediatric Extracorporeal Membrane Oxygenation Patients: A Single Institution’s Experience

Describe the prevalence of acquired von Willebrand syndrome in pediatric patients undergoing extracorporeal membrane oxygenation deemed to be at increased risk for the disease in our institution.

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Heparin-induced Thrombocytopenia in Pediatrics Following Cardiopulmonary Bypass

Heparin-induced thrombocytopenia (HIT) is an immune-mediated response to heparin administration.

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Proteomic Analysis of Infants Undergoing Cardiopulmonary Bypass Using Contemporary Ontological Tools

Cardiopulmonary bypass (CPB) is essential for the repair of many congenital cardiac defects in infants but is associated with significant derangements in hemostasis and systemic inflammation.

Neurologic Outcomes After Heart Surgery

Neurologic Outcomes After Heart Surgery

Patients who have undergone congenital heart surgery may appear outwardly normal, but their neurodevelopmental outcomes are often abnormal.

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Quality Improvement Project in Congenital Cardiothoracic Surgery Patients: Reducing Surgical Site Infections

Healthcare-associated infections are a major focus for quality improvement in hospitals today.

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Tranexamic Acid and Perioperative Bleeding in Children

Perioperative bleeding and blood product transfusion are associated with significant morbidity and mortality.

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Comparison of Two Cardiopulmonary Bypass Strategies With a Miniaturized Tubing System: a Propensity Score–based Analysis

The existing cardiopulmonary bypass tubing system has already been significantly improved in our hospital by reducing the priming volume; thus, we further employed a new cardiopulmonary bypass strategy in children based on a miniaturized cardiopulmonary bypass circuit.

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Fibrinogen Concentrate as an Alternative to Cryoprecipitate in a Postcardiopulmonary Transfusion Algorithm in Infants Undergoing Cardiac Surgery

Infants undergoing cardiac surgery are at risk for bleeding and massive transfusion due to an immature coagulation system, complex surgeries, and cardiopulmonary bypass (CPB) effects.

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Peritoneal Dialysis in Pediatric Postoperative Cardiac Surgical Patients

We determined the prevalence of acute kidney injury requiring peritoneal dialysis (PD), the factors associated with early PD initiation, prolonged PD and mortality among pediatric postoperative cardiac surgical patients.

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Establishing an ECMO Program in a Developing Country: Challenges and Lessons Learned

The ECMO (extracorporeal membrane oxygenation) Program at the American University of Beirut Medical Center was established in November 2015 as the first program serving adult and pediatric population in a low-resource setting.

ECMO Summary

Structured Review of Post-cardiotomy Extracorporeal Membrane Oxygenation: Part 2 – Pediatric Patients

Veno-arterial extracorporeal membrane oxygenation (ECMO) is established therapy for short-term circulatory support for children with life-treating cardiorespiratory dysfunction.

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Higher Flow on Cardiopulmonary Bypass in Pediatrics is Associated With A Lower Incidence of Acute Kidney Injury

This study examines two different perfusion strategies and their impact on various outcome measures including acute kidney injury (AKI), urine output on CPB, ICU length of stay, time to extubation, and mortality.

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Study Protocol: Nitric Oxide During Cardiopulmonary Bypass to Improve Recovery in Infants With Congenital Heart Defects (NITRIC Trial): A Randomised Controlled Trial

Congenital heart disease (CHD) is a major cause of infant mortality. Many infants with CHD require corrective surgery with most operations requiring cardiopulmonary bypass (CPB). CPB triggers a systemic inflammatory response which is associated with low cardiac output syndrome (LCOS), postoperative morbidity and mortality. Delivery of nitric oxide (NO) into CPB circuits can provide myocardial protection and reduce bypass-induced inflammation, leading to less LCOS and improved recovery.

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Postoperative Pain Management in Pediatric Patients Undergoing Cardiac Surgery: Where Are We Heading?

Adequate postoperative pain management is crucial in pediatric patients undergoing cardiac surgery because pain can lead to devastating short- and long-term consequences. This review discusses the limitations of current postoperative pain assessment and management in children after cardiac surgery, the obstacles to providing optimal treatment, and concepts to consider that may overcome these barriers.

Bill N Cover|Mission Checklist

Peritoneal Dialysis Vs Diuretics in Children After Congenital Heart Surgery

This study conducted a comprehensive search in Medline, EMBASE, Scopus, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews from the databases’ inception through April 24, 2018. Independent reviewers selected studies and extracted data. A random effects meta-analysis was performed to pool the outcomes of interest across studies.