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Comparison of Three Infant Venous Reservoirs with Vacuum-assisted Venous Drainage During Varying Levels of Cardiotomy Suction

There is an adverse effect of excessive cardiotomy suction on the efficacy of vacuum-assisted venous drainage in infant hard-shell venous reservoirs.

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Rationale and Design of the Steroids to Reduce Systemic Inflammation after Infant Heart Surgery (STRESS) Trial

The pragmatic “trial within a registry” design may provide a mechanism for conducting low cost, high efficiency trials in a heretofore-understudied patient population.

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The Organ-Protective Effect of Higher Partial Pressure of Arterial Carbon Dioxide in the Normal Range for Infant Patients Undergoing Ventricular Septal Defect Repair

The aim of this study was to determine whether a higher level of partial pressure of arterial carbon dioxide (PaCO2) within the normal range in pediatric patients undergoing cardiac surgery had an organ-protective effect.

Bill N Cover|Mission Checklist

Transfusing Platelets During Bypass Rewarming in Neonates Improves Postoperative Outcomes: A Randomized Controlled Trial

Platelet transfusion during the rewarming phase of neonatal cardiac surgery was associated with reduced bleeding and improved postoperative outcomes, compared to platelets given after coming off bypass.

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Post-operative Blood Loss is Higher Among African American Neonates Undergoing Open-heart Surgery with Cardiopulmonary Bypass for CHD

Among neonates with CHD undergoing open-heart surgery with cardiopulmonary bypass, African-American race is independently associated with greater chest tube output over the first 24 hours post-operatively.

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Venoarterial Extracorporeal Membrane Oxygenation Neck Cannulation: A Fixation Strategy Without Tourniquets

This article is focused on the peripheral neck cannulation technique.

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Common Inflammatory Markers After Cardiac Surgery in Infants and Their Relation to Blood Stream Sepsis

While leucocyte count, platelet count and C-Reactive Protein emerged as useful markers of post-operative inflammatory response and reaction to Cardiopulmonary Bypass, they proved unsatisfactory predictors of early post-operative sepsis.

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Safety and Efficacy of Tranexamic Acid in Paediatric Cardiac Surgery: Study Protocol for a Double-Blind Randomised Controlled Trial

An initial retrospective study suggested that tranexamic acid (TXA) administration increased the incidence of seizures in paediatric patients undergoing cardiac surgery.

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Extracorporeal Cardiopulmonary Resuscitation (ECPR): Initiation and Surgical Technique in the Pediatric Population

With the appropriate dedication of resources and personnel, ECPR has been shown to improve postoperative survival as compared to outcomes when this service is not available.

Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass

Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass

Dexmedetomidine is increasingly used off-label in infants and children with cardiac disease during cardiopulmonary bypass (CPB) and in the postoperative period.

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Part II. Comparison of Neurodevelopmental Outcomes Between Normothermic and Hypothermic Pediatric Cardiopulmonary Bypass

Our study did not reveal any significant differences in early neurodevelopmental outcomes between H-CPB or N-CPB surgery for congenital heart defects.

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Platelet Function Changes during Neonatal Cardiopulmonary Bypass Surgery: Mechanistic Basis and Lack of Correlation with Excessive Bleeding

Thrombocytopenia and platelet dysfunction induced by extracorporeal blood circulation are thought to contribute to postsurgical bleeding complications in neonates undergoing cardiac surgery with cardiopulmonary bypass (CPB).

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Recovery of Cefazolin and Clindamycin in In Vitro Pediatric CPB Systems

Recovery of cefazolin was high in the neonatal and infant CPB systems and moderate in the pediatric system. We found a large discrepancy between the theoretical and measured concentrations of clindamycin in all tested CPB systems.

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Cardiopulmonary Bypass Strategy to Facilitate Transfusion-Free Congenital Heart Surgery in Neonates and Infants

Bloodless CPB circuit priming should become a widespread reality, even in neonates and young infants, in any open-heart procedure.

Kidney Disease: Improving Global Outcomes in Neonates with Acute Kidney Injury After Cardiac Surgery

Kidney Disease: Improving Global Outcomes in Neonates with Acute Kidney Injury After Cardiac Surgery

Acute kidney injury (AKI) after cardiac surgery (CS-AKI) in children with congenital heart disease is a serious complication closely associated with high morbidity and mortality.

Bill N Cover|Mission Checklist

Toddler Neurodevelopmental Outcomes Are Associated With School-Age IQ in Children With Single Ventricle Physiology

To examine whether neurodevelopment at preschool age predicts IQ levels and needs for special education services in school-age children with single ventricle (SV) physiology.

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Ultrafiltration in Pediatric Cardiac Surgery Review

Ultrafiltration has some essential benefit as it is ubiquitously used at pediatric heart centers; however, the optimal protocol could be yet identified.

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Serum Levels of Interleukin-6, Interleukin-8, Interleukin-10, and Tumor Necrosis Factor-α, Renal Function Biochemical Parameters and Clinical Outcomes in Pediatric Cardiopulmonary Bypass Surgery

Higher circulatory pro-inflammatory cytokine level is associated with adverse outcomes such as increased intensive care unit stay and longer mechanical ventilation time in pediatric patients.

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Fresh Frozen Plasma versus Crystalloid Priming of Cardiopulmonary Bypass Circuit in Pediatric Surgery: A Randomized Clinical Trial

The results demonstrate that in infants and children, priming CPB with crystalloids does not result in a different risk of postoperative bleeding and need for transfusion of allogeneic blood products.

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Developments in Pediatric Ventricular Assist Device Support

Mechanical support devices have revolutionized the management of circulatory failure.

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Effect of Blood Flow on Platelets, Leukocytes, and Extracellular Vesicles in Thrombosis of Simulated Neonatal Extracorporeal Circulation

Extracorporeal membrane oxygenation (ECMO) has frequent and sometimes lethal thrombotic complications.

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Structured Review of Post-cardiotomy Extracorporeal Membrane Oxygenation: Part 2—Pediatric Patients

This report, aims to present a comprehensive overview of the available literature informing patient selection, ECMO management, and in-hospital and early post-discharge outcomes in pediatric patients treated with ECMO for post-cardiotomy cardiorespiratory failure.

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Early and Long-Term Outcomes Comparing Neonates, Infants, and Preadolescents Requiring Extracorporeal Membrane Oxygenation for Heart Failure

Veno-arterial extracorporeal membrane oxygenation is a lifesaving therapeutic chance for pediatric patients in the setting of either failure to wean from cardiopulmonary bypass or failed resuscitation from cardiac arrest.

Bill N Cover|Mission Checklist

Epidemiology of Acute Kidney Injury Among Paediatric Patients After Repair of Anomalous Origin of the Left Coronary Artery From the Pulmonary Artery

Acute kidney injury (AKI) is a prevalent complication after the surgical repair of paediatric cardiac defects and is associated with poor outcomes.