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Platelet Function Changes during Neonatal Cardiopulmonary Bypass Surgery: Mechanistic Basis and Lack of Correlation with Excessive Bleeding

Thrombocytopenia and platelet dysfunction induced by extracorporeal blood circulation are thought to contribute to postsurgical bleeding complications in neonates undergoing cardiac surgery with cardiopulmonary bypass (CPB).


Recovery of Cefazolin and Clindamycin in In Vitro Pediatric CPB Systems

Recovery of cefazolin was high in the neonatal and infant CPB systems and moderate in the pediatric system. We found a large discrepancy between the theoretical and measured concentrations of clindamycin in all tested CPB systems.

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Cardiopulmonary Bypass Strategy to Facilitate Transfusion-Free Congenital Heart Surgery in Neonates and Infants

Bloodless CPB circuit priming should become a widespread reality, even in neonates and young infants, in any open-heart procedure.

Kidney Disease: Improving Global Outcomes in Neonates with Acute Kidney Injury After Cardiac Surgery

Kidney Disease: Improving Global Outcomes in Neonates with Acute Kidney Injury After Cardiac Surgery

Acute kidney injury (AKI) after cardiac surgery (CS-AKI) in children with congenital heart disease is a serious complication closely associated with high morbidity and mortality.

Bill N Cover|Mission Checklist

Toddler Neurodevelopmental Outcomes Are Associated With School-Age IQ in Children With Single Ventricle Physiology

To examine whether neurodevelopment at preschool age predicts IQ levels and needs for special education services in school-age children with single ventricle (SV) physiology.


Ultrafiltration in Pediatric Cardiac Surgery Review

Ultrafiltration has some essential benefit as it is ubiquitously used at pediatric heart centers; however, the optimal protocol could be yet identified.


Serum Levels of Interleukin-6, Interleukin-8, Interleukin-10, and Tumor Necrosis Factor-α, Renal Function Biochemical Parameters and Clinical Outcomes in Pediatric Cardiopulmonary Bypass Surgery

Higher circulatory pro-inflammatory cytokine level is associated with adverse outcomes such as increased intensive care unit stay and longer mechanical ventilation time in pediatric patients.


Fresh Frozen Plasma versus Crystalloid Priming of Cardiopulmonary Bypass Circuit in Pediatric Surgery: A Randomized Clinical Trial

The results demonstrate that in infants and children, priming CPB with crystalloids does not result in a different risk of postoperative bleeding and need for transfusion of allogeneic blood products.

VAD|Nov 20|Paul

Developments in Pediatric Ventricular Assist Device Support

Mechanical support devices have revolutionized the management of circulatory failure.


Effect of Blood Flow on Platelets, Leukocytes, and Extracellular Vesicles in Thrombosis of Simulated Neonatal Extracorporeal Circulation

Extracorporeal membrane oxygenation (ECMO) has frequent and sometimes lethal thrombotic complications.

Street Ecmo 3

Structured Review of Post-cardiotomy Extracorporeal Membrane Oxygenation: Part 2—Pediatric Patients

This report, aims to present a comprehensive overview of the available literature informing patient selection, ECMO management, and in-hospital and early post-discharge outcomes in pediatric patients treated with ECMO for post-cardiotomy cardiorespiratory failure.


Early and Long-Term Outcomes Comparing Neonates, Infants, and Preadolescents Requiring Extracorporeal Membrane Oxygenation for Heart Failure

Veno-arterial extracorporeal membrane oxygenation is a lifesaving therapeutic chance for pediatric patients in the setting of either failure to wean from cardiopulmonary bypass or failed resuscitation from cardiac arrest.

Bill N Cover|Mission Checklist

Epidemiology of Acute Kidney Injury Among Paediatric Patients After Repair of Anomalous Origin of the Left Coronary Artery From the Pulmonary Artery

Acute kidney injury (AKI) is a prevalent complication after the surgical repair of paediatric cardiac defects and is associated with poor outcomes.


Peak Creatinine, Cardiopulmonary Bypass and Mortality After Stage One Single-ventricle Reconstruction

It is important to identify therapies which minimise complications associated with prolonged cardiopulmonary bypass duration in high risk populations.


Custodiol cardioplegia Solution Compared to Cold Blood cardioplegia in Pediatric Cardiac Surgery: a Single-institution Experience

Single-dose Custodiol is as safe as blood cardioplegia for myocardial protection in congenital cardiac surgery for the cross-clamp times evaluated in this study.

Bill N Cover|Mission Checklist

Impact of Cardiopulmonary Bypass and Aorta Cross Clamp Time on the Length of Mechanical Ventilation after Cardiac Surgery among Children: A Saudi Arabian Experience

According to our results, CPB and ACC time are not associated with PMV or prolonged hospital LOS.


Alkaline Phosphatase Treatment of Acute Kidney Injury in an Infant Piglet Model of Cardiopulmonary Bypass with Deep Hypothermic Circulatory Arrest

Acute kidney injury (AKI) is associated with prolonged hospitalization and mortality following infant cardiac surgery, but therapeutic options are limited.


Acquired von Willebrand Syndrome in Pediatric Extracorporeal Membrane Oxygenation Patients: A Single Institution’s Experience

Describe the prevalence of acquired von Willebrand syndrome in pediatric patients undergoing extracorporeal membrane oxygenation deemed to be at increased risk for the disease in our institution.

Shrink Wrapped

Heparin-induced Thrombocytopenia in Pediatrics Following Cardiopulmonary Bypass

Heparin-induced thrombocytopenia (HIT) is an immune-mediated response to heparin administration.


Proteomic Analysis of Infants Undergoing Cardiopulmonary Bypass Using Contemporary Ontological Tools

Cardiopulmonary bypass (CPB) is essential for the repair of many congenital cardiac defects in infants but is associated with significant derangements in hemostasis and systemic inflammation.

Neurologic Outcomes After Heart Surgery

Neurologic Outcomes After Heart Surgery

Patients who have undergone congenital heart surgery may appear outwardly normal, but their neurodevelopmental outcomes are often abnormal.


Quality Improvement Project in Congenital Cardiothoracic Surgery Patients: Reducing Surgical Site Infections

Healthcare-associated infections are a major focus for quality improvement in hospitals today.


Tranexamic Acid and Perioperative Bleeding in Children

Perioperative bleeding and blood product transfusion are associated with significant morbidity and mortality.


Comparison of Two Cardiopulmonary Bypass Strategies With a Miniaturized Tubing System: a Propensity Score–based Analysis

The existing cardiopulmonary bypass tubing system has already been significantly improved in our hospital by reducing the priming volume; thus, we further employed a new cardiopulmonary bypass strategy in children based on a miniaturized cardiopulmonary bypass circuit.

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