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5 Lactate prododuction

Frequency and Outcomes of Elevated Perioperative Lactate Levels in Adult Congenital Heart Disease Patients Undergoing Cardiac Surgery

Currently there is insufficient evidence to use lactate levels as a predictor of outcomes in adult patients with congenital heart disease undergoing cardiac surgery.

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In Vitro Recovery of Sufentanil, Midazolam, Propofol, and Methylprednisolone in Pediatric Cardiopulmonary Bypass Systems

The present in vitro experiment with neonatal, infant, and pediatric CPB systems shows a variable recovery of routinely used drugs with significant differences between drugs, but not between system categories (with the exception of propofol).


Fetal Cardiac Interventions: Where Do We Stand?

Fetal cardiac intervention (FCI) is a novel and evolving technique that allows for in utero treatment of a subset of congenital heart disease.


The Experience of Early Extubation After Paediatric Congenital Heart Surgery in a Chinese Hospital

Patients with early extubation had a lower reintubation rate and nasal continuous positive airway pressure rate, and a shorter length of stay in the ICU and hospital.


Pulsatile Flow is not a Magic Bullet for Congenital Heart Surgery Patients during CPB Procedures

The objective of this editorial is to clarify common myths related to the effects of pulsatile flow on circuit optimization and vital organ recovery in congenital heart surgery patients undergoing CPB

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Anticoagulation in Neonatal ECMO: An Enigma Despite a Lot of Effort!

This review provides an overview of hemostatic alterations, anticoagulation, monitoring and management, novel anticoagulant use, and circuit modifications for neonatal ECMO. Future considerations are also presented.


Impact of Delayed Systemic Heparinization on Postoperative Bleeding and Thromboembolism During Post-Cardiotomy Extracorporeal Membrane Oxygenation in Neonates

In this retrospective analysis, the results of delayed systemic heparinization in neonatal post-cardiotomy extracorporeal membrane oxygenation could lead one to conclude that this routine is safe and favorable with low risk for thromboembolic events, reduced postoperative hemorrhage, and reduced blood product utilization.


Lower Limit of Adequate Oxygen Delivery for the Maintenance of Aerobic Metabolism During Cardiopulmonary Bypass in Neonates

It was found that 340 ml min−1 m−2 is likely to represent the lowest suitable Ḋo2 required in neonates to maintain aerobic metabolism during normothermic CPB.


Use of Extracorporeal Membrane Oxygenation in Postcardiotomy Pediatric Patients: Parameters Affecting Survival

Parameters affecting mortality after extracorporeal membrane oxygenation support in pediatric postcardiotomy patient group were the presence of a syndrome, multiple runs of extracorporeal membrane oxygenation, and single-ventricular physiology.

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White Matter Brain Development after Exposure to Circulating Cell-Free Hemoglobin and Hyperoxia in a Rat Pup Model

In our model, exposure to circulatory cell-free Hb, with or without concomitant hyperoxia, did not significantly alter brain white matter development.


Selective Lower Body Perfusion During Aortic Arch Surgery in Neonates and Small Children

These findings show that a sufficient lower body perfusion through an arterial sheath placed in the femoral artery for aortic arch reconstruction can be achieved.


A Retrospective Analysis of the Use of 3-Factor Prothrombin Complex Concentrates for Refractory Bleeding After Cardiopulmonary Bypass in Children Undergoing Heart Surgery: A Matched Case-Control Study

These results suggest the safety of 3FPCC when used for refractory bleeding after cardiopulmonary bypass in children undergoing congenital heart surgery.

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Thrombin Generation and Antithrombin Activity in Infants Undergoing Cardiopulmonary Bypass—An Exploratory Study

In pediatric patients <10 kg undergoing cardiac surgery with CPB, thrombin generation and AT activity decline and do not recover completely after transfusion of platelets and cryoprecipitate.


Glial Fibrillary Acid Protein and Cerebral Oxygenation in Neonates Undergoing Cardiac Surgery

The potential value as a biomarker for cerebral injury after neonatal cardiac surgery warrants further investigation; in particular, the association with neurodevelopmental outcome needs to be determined.


Myocardial Protection in the Arterial Switch Operation: Custodiol Versus Cold Blood Cardioplegia

The optimal myocardial protective solution in the neonatal arterial switch operation remains controversial.


Single Ventricle Physiology Patients and Coagulation Abnormalities: Is There a Relationship With Hemodynamic Data and Postoperative Course? A Pilot Study

Abnormalities in coagulation parameters are common in SV patients. Coagulation abnormalities constitute a preoperative risk factor and affect postoperative course.

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Comparison of Three Infant Venous Reservoirs with Vacuum-assisted Venous Drainage During Varying Levels of Cardiotomy Suction

There is an adverse effect of excessive cardiotomy suction on the efficacy of vacuum-assisted venous drainage in infant hard-shell venous reservoirs.

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Rationale and Design of the Steroids to Reduce Systemic Inflammation after Infant Heart Surgery (STRESS) Trial

The pragmatic “trial within a registry” design may provide a mechanism for conducting low cost, high efficiency trials in a heretofore-understudied patient population.


The Organ-Protective Effect of Higher Partial Pressure of Arterial Carbon Dioxide in the Normal Range for Infant Patients Undergoing Ventricular Septal Defect Repair

The aim of this study was to determine whether a higher level of partial pressure of arterial carbon dioxide (PaCO2) within the normal range in pediatric patients undergoing cardiac surgery had an organ-protective effect.

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Transfusing Platelets During Bypass Rewarming in Neonates Improves Postoperative Outcomes: A Randomized Controlled Trial

Platelet transfusion during the rewarming phase of neonatal cardiac surgery was associated with reduced bleeding and improved postoperative outcomes, compared to platelets given after coming off bypass.


Post-operative Blood Loss is Higher Among African American Neonates Undergoing Open-heart Surgery with Cardiopulmonary Bypass for CHD

Among neonates with CHD undergoing open-heart surgery with cardiopulmonary bypass, African-American race is independently associated with greater chest tube output over the first 24 hours post-operatively.

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Venoarterial Extracorporeal Membrane Oxygenation Neck Cannulation: A Fixation Strategy Without Tourniquets

This article is focused on the peripheral neck cannulation technique.


Common Inflammatory Markers After Cardiac Surgery in Infants and Their Relation to Blood Stream Sepsis

While leucocyte count, platelet count and C-Reactive Protein emerged as useful markers of post-operative inflammatory response and reaction to Cardiopulmonary Bypass, they proved unsatisfactory predictors of early post-operative sepsis.


Safety and Efficacy of Tranexamic Acid in Paediatric Cardiac Surgery: Study Protocol for a Double-Blind Randomised Controlled Trial

An initial retrospective study suggested that tranexamic acid (TXA) administration increased the incidence of seizures in paediatric patients undergoing cardiac surgery.