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Leiters Partners with Hibernation Therapeutics to Provide Adenocaine™ Cardioplegic Solution

Leiters, a trusted FDA-registered 503B provider of high-quality compounded sterile preparations, announced today that it has entered into a national agreement with Hibernation Therapeutics to provide a patented cardioplegic solution developed by Hibernation Therapeutics known as Adenocaine™.

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Perioperative THR-184 and AKI after Cardiac Surgery

AKI after cardiac surgery is associated with mortality, prolonged hospital length of stay, use of dialysis, and subsequent CKD. We evaluated the effects of THR-184, a bone morphogenetic protein-7 agonist, in patients at high risk for AKI after cardiac surgery.

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Optimizing Perioperative Blood and Coagulation Management During Cardiac Surgery

This article reviews the hemostasis disturbances in cardiac surgery with cardiopulmonary bypass and gives an overview of the most important patient blood management strategies.

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Enhanced Activity by NKCC1 and Slc26a6 Mediates Acidic pH and Cl- Movement after Cardioplegia-Induced Arrest of db/db Diabetic Heart

Diabetic heart dysfunctions during cardiac surgeries have revealed several clinical problems associated with ion imbalance. However, the mechanism of ion imbalance mediated by cardioplegia and a diabetic heart is largely unclear.


Serum Lactate Poorly Predicts Central Venous Oxygen Saturation in Critically Ill Patients: a Retrospective Cohort Study

Serum lactate and central venous oxygen saturation (ScvO2) are commonly used and commonly recommended as markers of tissue oxygenation in shock states.

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Conscious Sedation Versus General Anesthesia in Transcatheter Aortic Valve Replacement: A Cost and Outcome Analysis

The use of conscious sedation (CS) as compared with general anesthesia (GA) has shown better clinical outcomes for TAVR patients.

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The Prognosis Impact of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Plus Cytoreductive Surgery (CRS) in Advanced Ovarian Cancer: The Meta-Analysis

Background and Objective Previous studies about the prognostic value of the HIPEC have yielded controversial results. Therefore, this study aims to assess the impact of HIPEC on patients with ovarian cancer. Results We included 13 comparative studies, and found that the overall survival (OS) and progression-free survival (PFS) in HIPEC groups were superior to groups…

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The Complexity of Atrial Fibrillation Newly Diagnosed After Ischemic Stroke and Transient Ischemic Attack: Advances and Uncertainties

Purpose of Review Atrial fibrillation is being increasingly diagnosed after ischemic stroke and transient ischemic attack (TIA). Patient characteristics, frequency and duration of paroxysms, and the risk of recurrent ischemic stroke associated with atrial fibrillation detected after stroke and TIA (AFDAS) may differ from atrial fibrillation already known before stroke occurrence. We aim to summarize…

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Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure

Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship exists between the two—AF exacerbates heart failure causing a significant increase in heart failure symptoms, admissions to hospital and cardiovascular death, while pathological remodeling of the atria as a result of heart failure increases the risk of AF. A comprehensive understanding of the…

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Cardiac and Vascular Surgery–Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group

Acute kidney injury (AKI) occurs in 7% to 18% of hospitalized patients and complicates the course of 50% to 60% of those admitted to the intensive care unit, carrying both significant mortality and morbidity. Even though many cases of AKI are reversible within days to weeks of occurrence, data from multiple large observational and epidemiological…


The Influence of Oxygen Delivery During Cardiopulmonary Bypass on the Incidence of Delirium in CABG Patients; A Retrospective Study

INTRODUCTION: Postoperative delirium is the most common neurological complication of cardiac surgery. Hypoxia has been shown to increase the risk of postoperative delirium. The possibility to continuously monitor oxygen delivery (DO2) during cardiopulmonary bypass(CPB) offers an adequate approximation of the oxygen status in a patient. This study investigates the role of oxygen delivery during cardiopulmonary bypass in the…

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Emergent Cardiac Surgery During Transcatheter Aortic Valve Implantation (TAVI): A Weighted Meta-Analysis of 9,251 Patients From 46 Studies

Refinement in transcatheter aortic valve implantation (TAVI) technology should not only focus on miniaturisation and improving flexibility of the delivery systems and/or devices -which may have the potential for decreasing aortic dissection, annular rupture, and tamponade- but also incorporate modifications to prevent embolisation/dislocation of the valve.

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Radial-Artery or Saphenous-Vein Grafts in Coronary-Artery Bypass Surgery

We performed a patient-level combined analysis of randomized, controlled trials to compare radial-artery grafts and saphenous-vein grafts for coronary-artery bypass grafting (CABG).

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Mitral Valve Surgery: Current Minimally Invasive and Transcatheter Options

In this article, we review current techniques for minimally invasive cardiac surgery (MICS) for mitral valve repair or replacement (MVR/r) and upcoming catheter-based therapies for the mitral valve.

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Goal-Directed Therapy in Cardiac Surgery: A Systematic Review and Meta-Analysis

There is evidence that perioperative goal-directed haemodynamic therapy (GDT) may reduce surgical mortality and morbidity in non-cardiac surgical patients, the data are less clear after cardiac surgery. The objective of this review is to perform a meta-analysis on the effects of perioperative GDT on mortality, morbidity, and length of hospital stay in cardiac surgical patients.

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Transcatheter Aortic Valve Implantation (TAVI) by Centers with and without an On-Site Cardiac Surgery Program: Preliminary Experience from the German TAVI Registry

This study analysed patient characteristics, decision-making processes, and outcomes of TAVI performed in hospitals with versus those without on-site cardiac surgery (CS).

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The Dutch Hospital Standardized Mortality Ratio (HSMR) Method and Cardiac Surgery: Benchmarking in a National Cohort Using Hospital Administration Data Versus a Clinical Database

The objective of this study is to compare the accuracy of data from hospital administration databases and a national clinical cardiac surgery database and to compare the performance of the Dutch hospital standardised mortality ratio (HSMR) method and the logistic European System for Cardiac Operative Risk Evaluation, for the purpose of benchmarking of mortality across hospitals.

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Five-Year Outcomes with PCI Guided by Fractional Flow Reserve

We hypothesized that fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) would be superior to medical therapy as initial treatment in patients with stable coronary artery disease.

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The Feasibility and Safety of Off-Pump Coronary Bypass Surgery in Emergency Revascularization

The efficacy and safety of off-pump coronary artery bypass grafting (OPCAB) in emergency revascularization remains controversial despite its widespread use. The aim of our study was to examine the applicability and safety of OPCAB in patients who were indicated for emergency surgery.

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Comparison of Immediate Extubation Versus Ultrafast Tracking Strategy in the Management of Off-Pump Coronary Artery Bypass Surgery

Ultrafast tracking of anesthesia (UFTA) is practiced routinely, whereas immediate on-table extubation after off-pump coronary artery bypass (OPCAB) grafting surgery has many concerns. The purpose of our study was to evaluate the safety and feasibility of immediate extubation (IE) versus UFTA.

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Off-Pump Coronary Artery Bypass Grafting with Mini-Sternotomy in the Treatment of Triple-Vessel Coronary Artery Disease

We have developed off-pump coronary artery bypass approach with lower distal mini-sternotomy (TM-OPCAB) for multivessel coronary revascularization. The aim of this retrospective study is to provide evidence for the feasibility and safety of this technique in the treatment of triple-vessel diseases.

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Early LVAD Implantation in a Patient with Left Ventricular Failure after Aortic Dissection with Left Main Stem Involvement

Coronary involvement in aortic dissection heralds a poor outcome. Involvement of the left main stem may lead to left ventricular (LV) failure requiring mechanical circulatory support.

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VV Extracorporeal Life Support for the Third Millennium: Will We Need Anticoagulation?

This review focuses on present day techniques for anticoagulation for ECLS and what future surface modifications may do to obviate the use of systemic anticoagulation entirely.

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Implementation of a Mechanical CPR Device in a Physician Staffed HEMS – A Prospective Observational Study

In this prospective, observational study we describe the incidence and characteristics of out of hospital cardiac arrest (OHCA) cases who received mechanical CPR, after the implementation of a mechanical CPR device.