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SARS-CoV-2 Infection and Cardiovascular Disease: COVID-19 Heart

In this review, we summarise the cardiac manifestations of COVID-19 infection and propose a simplified algorithm for patient management during the COVID-19 pandemic.


Risk of COVID-19 Among Front-Line Health-Care Workers and the General Community: A Prospective Cohort Study.

Health-care systems should ensure adequate availability of PPE and develop additional strategies to protect health-care workers from COVID-19, particularly those from Black, Asian, and minority ethnic backgrounds.


Extracorporeal Life Support Organization Coronavirus Disease 2019 Interim Guidelines: A Consensus Document from an International Group of Interdisciplinary Extracorporeal Membrane Oxygenation Providers

These guidelines are not meant to replace sound clinical judgment or specialist consultation but rather to strengthen provision and clinical management of ECMO specifically, in the context of the COVID-19 pandemic.

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COVID-19: Coagulopathy, Risk of Thrombosis, and the Rationale for Anticoagulation

Besides the anticoagulant effect of LMWH, nonanticoagulant properties such as the reduction in interleukin 6 release have been shown to improve the complex picture of coagulopathy in patients with COVID-19.

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Has Venoarterial Ecmo Been Underutilized in Covid-19 Patients?

This outbreak of infectious disease could enable an improved understanding of ARDS and a more precise use of therapeutics as ECMO and different configurations with a tailor-made treatment.

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Education and Scientific Dissemination during the Covid-19 Pandemic

This editorial outlines how education and scientific dissemination at the Association of Anaesthetists has continued throughout the pandemic, as well as exploring likely future directions for such activities.

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Perioperative Management of COVID-19 Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass

The following report will recommend perioperative guidance in patient management to include safety precautions for the heart team, the conduct of extracorporeal circulation and related equipment, and covering the early period in intensive care in the context of the current pandemic.


Cytokine Adsorption in Patients with Severe COVID-19 Pneumonia Requiring Extracorporeal Membrane Oxygenation

With this study, we expect to clarify whether cytokine adsorption is beneficial in severely affected COVID-19 patients requiring vv-ECMO support.

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American Experience with Extracorporeal Support in Covid-19 Patients: Early Outcomes from a Single Institution

As the world learned about Covid-19, the application of ECMO also evolved as health systems in the United States had some time to prepare. We report our initial experience using extracorporeal support for Covid-19 patients with the resource challenges that attend a worldwide pandemic.


Thrombosis and Coagulopathy in COVID‐19: An Illustrated Review

There appear to be high rates of venous thromboembolism and also, what has been poorly described before in acute lung injury, a high rate of pulmonary immunothrombosis (thrombosis secondary to inflammation).

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Is a “Cytokine Storm” Relevant to COVID-19?

A critical evaluation of the term cytokine storm and its relevance to COVID-19 is warranted.

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The role of ECMO in COVID-19: Can it Provide Rescue Therapy in Those Who Are Critically Ill?

Our understanding of COVID‐19 is ever‐changing and the need for intensive care beds is rising, which means that ECMO will surely play a key role in the near future.

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Cardiovascular Consequences and Considerations of Coronavirus Infection – Perspectives for the Cardiothoracic Anesthesiologist and Intensivist During the Coronavirus Crisis

The unique considerations of this important infection significantly affect the management approaches to these patients by cardiothoracic anesthesiologists and intensivists with respect to airway management, echocardiography, anesthetic care, and extracorporeal membrane oxygenation.

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ECMO Use in COVID-19: Lessons from Past Respiratory Virus Outbreaks—a Narrative Review

Here, we review the experience with the use of ECMO in the past respiratory virus outbreaks and discuss potential role for ECMO in COVID-19.

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Haemoglobin Oxygen Affinity in Patients with Severe COVID‐19 Infection

We have measured Hb O2 affinity curves from severely ill COVID‐19 patients and, in comparison to age‐ and sex‐matched controls, find no evidence for a shift in O2 affinity that would support any change in clinical management.

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Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research

It is our hope that the present document will encourage and stimulate future prospective studies and randomized trials to study the safety, efficacy, and optimal use of these agents for prevention or management of thrombosis in COVID-19.


Charting a Safe and Expeditious Course Back to Elective Cardiac Surgery During the COVID-19 Pandemic

What has become clear amidst the flux and uncertainty of the pandemic is that we must find a way to remain available to our patients by charting a safe and expeditious path toward resumption of elective cardiac surgery.


Mortality and Pulmonary Complications in Patients Undergoing Surgery with Perioperative SARS-CoV-2 Infection: an International Cohort Study

Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery.

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Managing Teamwork in the Face of Pandemic: Evidence-based Tips

We hope the evidence-based tips we provided about teamwork under stress can be used by healthcare providers, team leaders and management to take constructive actions both during and in the early aftermath of the COVID-19 pandemic.

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Recognizing and Supporting Morally Injured ICU Professionals during the COVID‑19 Pandemic

A person becomes morally injured if exposed to repeated incidents of moral distress or due to a single egregious violation of morality.


Extracorporeal Oxygenation and COVID-19 Epidemic is the Membrane Fail-Safe to Cross Contamination?

We concluded that it is possible for SARS-CoV-2 to cross the membrane and aerosolize through the gas-exit port of the membrane lung. This phenomenon might be dependent on the presence of viral traces in the bloodstream and on the occurrence of fibers damage, which are both considered rare scenarios.


Fibrinolysis Shutdown Correlates to Thromboembolic Events in Severe COVID-19 Infection

Fibrinolysis shutdown, as evidenced by elevated D-Dimer and complete failure of clot lysis at 30 minutes on thromboelastography, predicts thromboembolic events and need for hemodialysis in critically ill patients with COVID-19. Further clinical trials are required to ascertain the need for early therapeutic anticoagulation or fibrinolytic therapy to address this state of fibrinolysis shutdown.


Veno-venous Extracorporeal Membrane Oxygenation for Respiratory Failure in COVID-19 Patients

This is 1 the first case series describing VV ECMO outcomes in COVID-19 patients. Our initial data suggest that VV ECMO can be successfully utilized in appropriately selected COVID-19 patients with advanced respiratory failure.


The COVID-19 Outbreak and its Impact on Hospitals in Italy: the Model of Cardiac Surgery

Whatever the strategy adopted, it is still unknown how this will impact the future needs of elective cardiac surgical procedures as well as of other procedures (e.g. neurosurgery) which cannot be performed with an inadequate availability of ICU beds.