Extracorporeal Membrane Oxygenation Support In COVID-19: An International Cohort Study of The Extracorporeal Life Support Organization Registry
In patients with COVID-19 who received ECMO, both estimated mortality 90 days after ECMO and mortality in those with a final disposition of death or discharge were less than 40%. These data from 213 hospitals worldwide provide a generalisable estimate of ECMO mortality in the setting of COVID-19.
COVID-19: FAQs in Pediatric Cardiac Surgery—A Sequel
Our knowledge of the COVID-19 pandemic continues to grow rapidly, leading to further clarity and revealing new questions in turn, thus it is critically important that clinician knowledge is updated frequently.
ISTH DIC Subcommittee Communication on Anticoagulation In COVID-19
Although the current evidence is still insufficient, we provide a pragmatic approach to anticoagulation in COVID‐19, but stress the need for further trials in this area.
COVID-19 Associated Hypercoagulability Manifestations, Mechanisms, and Management
In this narrative review, we summarize clinical manifestations of COVID-19, mechanisms, monitoring considerations, and anticoagulant therapy. We also review unique considerations for COVID-19 patients who are on extracorporeal membrane oxygenation.
Extracorporeal Blood Purification Treatment Options For COVID-19: The Role of Immunoadsorption
Several extracorporeal blood purification therapies are now available, and most of them target endotoxins and/or the cytokines and aim improving the immune response. For this purpose, plasmapheresis and immunoadsorption may be an important adjunctive treatment option to manage the complications caused by cytokine storm in critically ill patients with COVID-19.
Thromboelastography Profiles of Critically Ill Patients With Coronavirus Disease 2019
A large proportion of critically ill patients with coronavirus disease 2019 have hypercoagulable thromboelastography profiles with additional derangements related to fibrinogen and platelet function. As the majority of patients have an elevated thromboelastography maximum amplitude, a follow-up study evaluating platelet aggregation would be instructive.
Cardiovascular Manifestations and Treatment Considerations In COVID-19
COVID-19 contributes to cardiovascular complications, including acute myocardial injury as a result of acute coronary syndrome, myocarditis, stress-cardiomyopathy, arrhythmias, cardiogenic shock, and cardiac arrest.
Early Respiratory Outcomes Following Cardiac Surgery in Patients With COVID-19
Although early respiratory outcomes of asymptomatic COVID‐19 patients who underwent early cardiac surgery appeared to be satisfactory, compared to the propensity‐scored matched non‐COVID group, the postoperative outcomes were worse, especially in the ICU readmitted patients. We suggest postponing cardiac operations unless the patient requires emergency surgery.
Role of Extracorporeal Membrane Oxygenation In COVID-19: A Systematic Review
Our study highlights the paucity of evidence and the need for further data to consolidate the efficacy of ECMO in improving patient outcomes.
Sulfated Polysaccharides Effectively Inhibit SARS-Cov-2 In Vitro
To this end, we suggest that treatment of fucoidans, nebulized heparin, or possibly TriS-heparin in combination with or without current antiviral therapies, should be assessed first in human primary epithelial cells and then in human patients suffering from COVID-19.
Approach to Acute Cardiovascular Complications in COVID-19 Infection
This review discusses the presentation and management of patients with severe cardiac complications of COVID-19 disease, with an emphasis on a Heart-Lung team approach in patient management.
Provision of ECPR during COVID-19: Evidence, Equity, and Ethical Dilemmas
The logistics of patient selection, expedient cannulation, healthcare worker safety, and post-resuscitation care must be weighed against the ethical considerations.
COVID-19: Myocardial Injury in Survivors
In summary, myocardial injury is common in hospitalized COVID-19 patients and not exclusive to those with ACS or PE. In this single-centre, single-timepoint convalescent study, myocardial injury was associated with cardiac abnormalities detected by CMR where troponin elevation is unexplained even when cardiac function is normal.
Therapeutic Plasma Exchange: A potential Management Strategy for Critically Ill COVID-19 Patients
Herein, we briefly discuss some of the various approaches currently being investigated for the treatment of SARS-CoV-2 with a focus on potential benefits of TPE for selected critically ill patients.
SARS-CoV-2 Infection and Cardiovascular Disease: COVID-19 Heart
In this review, we summarise the cardiac manifestations of COVID-19 infection and propose a simplified algorithm for patient management during the COVID-19 pandemic.
Risk of COVID-19 Among Front-Line Health-Care Workers and the General Community: A Prospective Cohort Study.
Health-care systems should ensure adequate availability of PPE and develop additional strategies to protect health-care workers from COVID-19, particularly those from Black, Asian, and minority ethnic backgrounds.
Extracorporeal Life Support Organization Coronavirus Disease 2019 Interim Guidelines: A Consensus Document from an International Group of Interdisciplinary Extracorporeal Membrane Oxygenation Providers
These guidelines are not meant to replace sound clinical judgment or specialist consultation but rather to strengthen provision and clinical management of ECMO specifically, in the context of the COVID-19 pandemic.
COVID-19: Coagulopathy, Risk of Thrombosis, and the Rationale for Anticoagulation
Besides the anticoagulant effect of LMWH, nonanticoagulant properties such as the reduction in interleukin 6 release have been shown to improve the complex picture of coagulopathy in patients with COVID-19.
Has Venoarterial Ecmo Been Underutilized in Covid-19 Patients?
This outbreak of infectious disease could enable an improved understanding of ARDS and a more precise use of therapeutics as ECMO and different configurations with a tailor-made treatment.
Education and Scientific Dissemination during the Covid-19 Pandemic
This editorial outlines how education and scientific dissemination at the Association of Anaesthetists has continued throughout the pandemic, as well as exploring likely future directions for such activities.
Perioperative Management of COVID-19 Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass
The following report will recommend perioperative guidance in patient management to include safety precautions for the heart team, the conduct of extracorporeal circulation and related equipment, and covering the early period in intensive care in the context of the current pandemic.
Cytokine Adsorption in Patients with Severe COVID-19 Pneumonia Requiring Extracorporeal Membrane Oxygenation
With this study, we expect to clarify whether cytokine adsorption is beneficial in severely affected COVID-19 patients requiring vv-ECMO support.
American Experience with Extracorporeal Support in Covid-19 Patients: Early Outcomes from a Single Institution
As the world learned about Covid-19, the application of ECMO also evolved as health systems in the United States had some time to prepare. We report our initial experience using extracorporeal support for Covid-19 patients with the resource challenges that attend a worldwide pandemic.