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Heparin Dose Response Is Independent of Perioperative Antithrombin Activity in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Low Heparin Concentrations

Heparin Dose Response Is Independent of Perioperative Antithrombin Activity in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Low Heparin Concentrations

We hypothesized that there would be a direct association between perioperative AT activity and both heparin dose response (HDR) and heparin sensitivity index (HSI) in patients undergoing coronary artery bypass graft surgery.

Preoperative Heparin Therapy Causes Immune-Mediated Hypotension Upon Heparin Administration for Cardiac Surgery

Preoperative Heparin Therapy Causes Immune-Mediated Hypotension Upon Heparin Administration for Cardiac Surgery

To evaluate whether patients with positive or negative heparin antibodies who received heparin preoperatively by continuous infusion developed cardiovascular changes upon heparin administration prior to cardiopulmonary bypass.

Predonation of Autologous Blood Reduces Perioperative Allogenic Transfusion Requirement In Grown-up Patients With Congenital Heart Disease

Predonation of Autologous Blood Reduces Perioperative Allogenic Transfusion Requirement In Grown-up Patients With Congenital Heart Disease

To investigate the efficacy of autologous blood predonation (ABP), we focussed on a homogeneous subgroup of patients, with right ventricular outflow tract reconstruction.

Meta-Analysis of Clinical Studies of the Purported Deleterious Effects of “Old” (Versus “Fresh”) Red Blood Cells: Are We at Equipoise?

Meta-Analysis of Clinical Studies of the Purported Deleterious Effects of “Old” (Versus “Fresh”) Red Blood Cells: Are We at Equipoise?

A meta-analysis examined whether the available data support an adequate suspicion that transfusion of old red blood cells (RBCs) is associated with increased mortality, organ failure, infection, prolonged mechanical ventilation, and prolonged stay in the hospital or the intensive care unit.

Hematocrit on Cardiopulmonary Bypass and Outcome After Coronary Surgery in Nontransfused Patients

Hematocrit on Cardiopulmonary Bypass and Outcome After Coronary Surgery in Nontransfused Patients

This study aimed to identify the role of preoperative anemia and hemodilution during cardiopulmonary bypass as determinants of morbidity and mortality after coronary operations.

Argatroban as a Aubstitute of Heparin During Cardiopulmonary Bypass: A Safe Alternative?

Argatroban as a Aubstitute of Heparin During Cardiopulmonary Bypass: A Safe Alternative?

The objective of this communication is to report our recent experience with this agent during cardiopulmonary bypass (CPB) and to review the cases previously published in order to better define indications, dosage, monitoring and limitations in cardiac surgery patients.

The Inflammatory Response to Miniaturised Extracorporeal Circulation: A Review of the Literature

The Inflammatory Response to Miniaturised Extracorporeal Circulation: A Review of the Literature

This review focuses on the inflammatory and clinical outcomes of using MECC and compares these to conventional cardio-pulmonary bypass (CCPB).

Blood Transfusion is Associated With Increased Morbidity and Mortality after Lower Extremity Revascularization

Blood Transfusion is Associated With Increased Morbidity and Mortality after Lower Extremity Revascularization

We queried the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database to examine the effect of intraoperative blood transfusion on the morbidity and mortality in patients who underwent lower extremity revascularization.

Microemboli in Our Bypass Circuits: A Contemporary Audit

Microemboli in Our Bypass Circuits: A Contemporary Audit

We used the Emboli Detection and Classification quantifier (EDAC) (Luna Innovations, Roanoke, VA) in a prospective clinical audit of emboli in a contemporary CPB circuit.

Modified Ultrafiltration with the Hemobag (Video)

Modified Ultrafiltration with the Hemobag (Video)

Scott Pacheco discusses his clinical experiences with the Hemobag at Palmetto Regional Hospital (27 minutes).

Duration of Red Blood Cell Storage and Outcomes in Pediatric Cardiac Surgery: An Association Found for Pump Prime Blood

Duration of Red Blood Cell Storage and Outcomes in Pediatric Cardiac Surgery: An Association Found for Pump Prime Blood

The purpose of this study was to investigate the influence of red blood cell storage time prior to transfusion on postoperative morbidity in pediatric cardiac operations.

Activity-Based Costs of Blood Transfusions in Surgical Patients at Four Hospitals

Activity-Based Costs of Blood Transfusions in Surgical Patients at Four Hospitals

Determining the cost of supplying patients with blood transfusions requires an in-depth examination of the complex array of activities surrounding the decision to transfuse.

Complications of Recombinant Activated Human Coagulation Factor VII

Complications of Recombinant Activated Human Coagulation Factor VII

Recombinant factor VIIa (rFVIIa) frequently is used for treatment of life-threatening hemorrhage in trauma.

Open Heart Surgery in Patients With Sickle Cell Hemoglobinopathy

Open Heart Surgery in Patients With Sickle Cell Hemoglobinopathy

The aim of this study was to review retrospectively the perioperative results of patients undergoing cardiac surgery at our institution.

Despite Modern Off-pump Coronary Artery Bypass Grafting Women Fare Worse Than Men

Despite Modern Off-pump Coronary Artery Bypass Grafting Women Fare Worse Than Men

Herein, we evaluate if gender has an impact on outcomes after modern off-pump coronary artery bypass grafting (OPCAB).

Near-Infrared Spectroscopy Technique to Evaluate the Effects of Red Blood Cell Transfusion on Tissue Oxygenation

Near-Infrared Spectroscopy Technique to Evaluate the Effects of Red Blood Cell Transfusion on Tissue Oxygenation

The aim of this study was to evaluate the effects of red blood cell (RBC) transfusions on muscle tissue oxygenation, oxygen metabolism and microvascular reactivity in critically ill patients using near-infrared spectroscopy (NIRS) technology.

Profound Effects of Cardiopulmonary Bypass Priming Solutions on the Fibrin Part of Clot Formation: An Ex Vivo Evaluation Using Rotation Thromboelastometry

Profound Effects of Cardiopulmonary Bypass Priming Solutions on the Fibrin Part of Clot Formation: An Ex Vivo Evaluation Using Rotation Thromboelastometry

Therefore, the authors investigated whether hemodilution with different priming solutions distinctly affects the fibrinogen-mediated step in whole blood clot formation.

Benefits and Risks of Maintaining Normothermia during Cardiopulmonary Bypass in Adult Cardiac Surgery: A Systematic Review

Benefits and Risks of Maintaining Normothermia during Cardiopulmonary Bypass in Adult Cardiac Surgery: A Systematic Review

This review assessed the benefits and risks of maintaining normothermia during cardiopulmonary bypass in adult cardiac surgery.

A Point-of-Care Assessment of the Effects of Desmopressin on Impaired Platelet Function Using Multiple Electrode Whole-Blood Aggregometry in Patients After Cardiac Surgery

A Point-of-Care Assessment of the Effects of Desmopressin on Impaired Platelet Function Using Multiple Electrode Whole-Blood Aggregometry in Patients After Cardiac Surgery

In this study, we examined the feasibility of whole blood multiple electrode aggregometry (MEA) for the detection of cardiopulmonary bypass-induced platelet dysfunction and investigated its ability to monitor DDAVP treatment.

Lifebridge B2T-A New Portable Cardiopulmonary Bypass System

Lifebridge B2T-A New Portable Cardiopulmonary Bypass System

The LIFEBRIDGE B2T is a new portable cardiopulmonary bypass (CPB) system designed for temporary circulatory support.

The Influence of the Residual Stress in Silicone Tubes in the Calibration Methods of Roller Pumps Used in Cardiopulmonary Bypass

The Influence of the Residual Stress in Silicone Tubes in the Calibration Methods of Roller Pumps Used in Cardiopulmonary Bypass

This study evaluated the influence of silicone tubing residual stress found on pump regulation. Silicone tubes obtained from two different suppliers were used in 6-inch DeBakey roller pumps.

Fresh Frozen Plasma Is Independently Associated With a Higher Risk of Multiple Organ Failure and Acute Respiratory Distress Syndrome

Fresh Frozen Plasma Is Independently Associated With a Higher Risk of Multiple Organ Failure and Acute Respiratory Distress Syndrome

Blood transfusion is known to be an independent risk factor for mortality, multiple organ failure (MOF), acute respiratory distress syndrome (ARDS), and nosocomial infection after injury.

Transfusion and Pulmonary Morbidity After Cardiac Surgery

Transfusion and Pulmonary Morbidity After Cardiac Surgery

Our objective was to determine the prevalence of pulmonary morbidity related to transfusion and whether TRALI consensus-criteria are applicable to cardiac surgery.

High-Dose Erythropoietin in Patients with Acute Myocardial Infarction: A Pilot, Randomised, Placebo-Controlled Study

High-Dose Erythropoietin in Patients with Acute Myocardial Infarction: A Pilot, Randomised, Placebo-Controlled Study

The aim of this single-centre study was to investigate the effects of short-term high-dose erythropoietin on peripheral blood cells (PBCs) and infarct size in 30 patients with a first uncomplicated AMI undergoing percutaneous coronary intervention (PCI) who were randomly assigned to treatment with EPO (33×10(3)IU before PCI, and 24 and 48h after admission), or placebo.