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Surgery for Aneurysms of the Aortic Root: A 30-Year Experience

Surgery for Aneurysms of the Aortic Root: A 30-Year Experience

Aortic root replacement for aortic root aneurysms can be done with low morbidity and mortality. Composite valve conduit reconstruction resulted in a durable result. There were few serious complications related to the need for long-term anticoagulation or a prosthetic valve.

Out-Patients Treated With Nesiritide Show Reduced Cardio Remodeling, Significant Improvements in Heart Function

Out-Patients Treated With Nesiritide Show Reduced Cardio Remodeling, Significant Improvements in Heart Function

Left ventricular remodeling and mitral and tricuspid regurgitation frequently follow myocardial injury, and are associated with worsening symptoms following heart failure.

In Vitro Effects of Poly-N-Acetyl Glucosamine on the Activation of Platelets in Platelet-Rich Plasma With and Without Red Blood Cells

In Vitro Effects of Poly-N-Acetyl Glucosamine on the Activation of Platelets in Platelet-Rich Plasma With and Without Red Blood Cells

Poly-N-acetyl glucosamine slurry activates platelets.

Effects of Low Temperature on Shear-Induced Platelet Aggregation and Activation

Effects of Low Temperature on Shear-Induced Platelet Aggregation and Activation

We found that platelets are hyper-reactive to fluid shear stress at temperatures of 24, 32, and 35 degrees C as compared with at 37 degrees C. The hyperreactivity results in heightened aggregation through a platelet-activation independent mechanism.

Perfusion.com Content Available Via RSS Syndication

Perfusion.com Content Available Via RSS Syndication

Perfusion.com News is now available through the Perfusion.com RSS service. With Perfusion.com RSS, you can take our news and article headlines, free of charge, for individual, non-commercial use and incorporate them into your preferred newsreaders and web logs.

Aortic Valve Replacement With the Jostra MECC System Versus Standard Cardiopulmonary Bypass: A Randomized Prospective Trial

Aortic Valve Replacement With the Jostra MECC System Versus Standard Cardiopulmonary Bypass: A Randomized Prospective Trial

BACKGROUND: We prospectively evaluated a newly introduced minimal extracorporeal circulation system (Jostra MECC System; Jostra AG, Hirrlingen, Germany) for aortic valve surgery. METHOD: In a prospective, randomized study, 100 patients underwent aortic valve replacement either with standard cardiopulmonary bypass (n = 50, group B) or with the MECC System (n = 50, group B). The…

Effect of Aprotinin on Clinical Outcomes in Coronary Artery Bypass Graft Surgery

Effect of Aprotinin on Clinical Outcomes in Coronary Artery Bypass Graft Surgery

OBJECTIVE: Despite proven blood transfusion benefits, aprotinin may be underused in coronary artery bypass grafting. Reluctance to use aprotinin may stem from safety concerns. The current objective was to evaluate clinical outcomes (mortality, myocardial infarction, renal failure, stroke, atrial fibrillation) in patients undergoing coronary artery bypass grafting who receive aprotinin by performing a quantitative overview…

Aortic Valve Replacement With the Jostra MECC System Versus Standard Cardiopulmonary Bypass: A Randomized Prospective Trial

Aortic Valve Replacement With the Jostra MECC System Versus Standard Cardiopulmonary Bypass: A Randomized Prospective Trial

BACKGROUND: We prospectively evaluated a newly introduced minimal extracorporeal circulation system (Jostra MECC System; Jostra AG, Hirrlingen, Germany) for aortic valve surgery. METHOD: In a prospective, randomized study, 100 patients underwent aortic valve replacement either with standard cardiopulmonary bypass (n = 50, group B) or with the MECC System (n = 50, group B). The…

Effect of Aprotinin on Clinical Outcomes in Coronary Artery Bypass Graft Surgery

Effect of Aprotinin on Clinical Outcomes in Coronary Artery Bypass Graft Surgery

OBJECTIVE: Despite proven blood transfusion benefits, aprotinin may be underused in coronary artery bypass grafting. Reluctance to use aprotinin may stem from safety concerns. The current objective was to evaluate clinical outcomes (mortality, myocardial infarction, renal failure, stroke, atrial fibrillation) in patients undergoing coronary artery bypass grafting who receive aprotinin by performing a quantitative overview…

Clopidogrel Did Not Inhibit Platelet Function Early After Coronary Bypass Surgery: A Prospective Randomized Trial

Clopidogrel Did Not Inhibit Platelet Function Early After Coronary Bypass Surgery: A Prospective Randomized Trial

OBJECTIVE: Although the beneficial effect of aspirin prescription after coronary surgery has been established, the efficacy of clopidogrel has never been compared with that of aspirin in the critical early postoperative period. We therefore conducted a prospective, double-blind, randomized controlled trial to compare the efficacies of these antiplatelet regimens. METHODS: Patients undergoing elective primary coronary…

Radiofrequency Ablation Prevents Lethal Arrhythmias in Children With WPW

Radiofrequency Ablation Prevents Lethal Arrhythmias in Children With WPW

Prophylactic radiofrequency ablation reduces the risk of life-threatening arrhythmias in children with asymptomatic Wolff-Parkinson-White syndrome (WPW), according to a report in the September 16th issue of The New England Journal of Medicine. “The findings of this study should reassure physicians and parents alike that in children with WPW who are at high risk for arrhythmias,…

Saint Francis Heart Hospital – Completely Paperless, All-Digital Network

Saint Francis Heart Hospital – Completely Paperless, All-Digital Network

Oklahoma: Tulsa-based Saint Francis Heart Hospital has switched to a “completely paperless…all-digital” network. The new system has reduced patient wait times to 10 minutes from an “industry average” of 30 minutes and allows lab results to be posted within 30 minutes of completion. The system was implemented by GE Healthcare over a nine-month period (Tulsa…

Disseminated Intravascular Coagulation: A Summary Review

Disseminated Intravascular Coagulation: A Summary Review

Disseminated intravascular coagulation is a condition in which small blood clots develop throughout the bloodstream, blocking small blood vessels and depleting the platelets and clotting factors needed to control bleeding. Disseminated intravascular coagulation (DIC) begins with excessive clotting. The excessive clotting is usually stimulated by a substance that enters the blood as part of a…

Comparison of a Duraflo II-Coated Cardiopulmonary Bypass Circuit and a Trillium-Coated Oxygenator During Open-Heart Surgery

Comparison of a Duraflo II-Coated Cardiopulmonary Bypass Circuit and a Trillium-Coated Oxygenator During Open-Heart Surgery

BACKGROUND: Cardiopulmonary bypass (CPB) evokes a systemic inflammatory response. In attempting to improve the biocompatibility of the equipment, various methods to coat the inner surfaces of the CPB systems have been developed. The present study compares a Trillium Biopassive surface-coated Affinity oxygenator with a Duraflo II totally heparin-coated CPB system. METHODS: Low-risk patients admitted for…

Methylprednisolone Prevents Inflammatory Reaction Occurring During Cardiopulmonary Bypass: Effects on TNF-, IL-6, IL-8, IL-10

Methylprednisolone Prevents Inflammatory Reaction Occurring During Cardiopulmonary Bypass: Effects on TNF-, IL-6, IL-8, IL-10

Objective: This study examined the correlation between tumour necrosis factor-alfa (TNF-), interleukin (IL)-6 and IL-8, IL-10 and methylprednisolone pretreatment. Methods: This is a prospective, randomized and double-blinded study. Sixty patients undergoing coronary artery bypass grafting (CABG) were randomized to receive either intravenous methylprednisolone (n = 30, Group M) or intravenous placebo (n = 30, Group…

Growth Factors and Cytokines

Growth Factors and Cytokines

A complete summary of platelet growth factors and cytokines.

Perfusion.com Inc. Privacy Statement and Policy

Perfusion.com Inc. Privacy Statement and Policy

Introduction Perfusion.com is committed to protecting your privacy and developing technology that gives you the most powerful and safe online experience. This Statement of Privacy applies to all the Perfusion.com websites and governs data collection and usage. By using the Perfusion.com websites, you consent to the data practices described in this statement.Collection of your Personal…

Capillary Leakage in Cardiac Surgery with Cardiopulmonary Bypass

Capillary Leakage in Cardiac Surgery with Cardiopulmonary Bypass

Abstract: Cardiopulmonary bypass causes a systemic inflammatory response, which can lead to capillary leak syndrome. In 15 adults undergoing elective cardiac surgery with cardiopulmonary bypass, we determined the volume and peak time of capillary leakage from the measurements of extracellular fluid volume and circulating blood volume taken preoperatively, at various intervals up to 24 hours…

Blood-Air Interface during Cardiopulmonary Bypass

Blood-Air Interface during Cardiopulmonary Bypass

Abstract: The aim of this study was to compare the systemic blood activation with open and closed perfusion management during cardiopulmonary bypass. In 30 patients undergoing coronary artery bypass grafting, we prospectively studied systemic blood activation, blood loss and the need for donor blood. In 15 patients we used an open venous reservoir consisting of…

Advantages of Subclavian Artery Perfusion for Repair of Acute Type A Dissection

Advantages of Subclavian Artery Perfusion for Repair of Acute Type A Dissection

Objective: Arterial perfusion through the right subclavian artery is proposed to avoid intraoperative malperfusion during repair of acute type A dissection. This study evaluated the clinical and neurological outcome of patients undergoing surgery of acute aortic type A dissection following subclavian arterial cannulation compared to femoral artery approach. Methods: From 1/97 to 1/03, 122 consecutive…

Advantages of Subclavian Artery Perfusion for Repair of Acute Type A Dissection

Advantages of Subclavian Artery Perfusion for Repair of Acute Type A Dissection

Objective: Arterial perfusion through the right subclavian artery is proposed to avoid intraoperative malperfusion during repair of acute type A dissection. This study evaluated the clinical and neurological outcome of patients undergoing surgery of acute aortic type A dissection following subclavian arterial cannulation compared to femoral artery approach. Methods: From 1/97 to 1/03, 122 consecutive…

Temperature Monitoring During Cardiopulmonary Bypass-Do We Undercool or Overheat the Brain?

Temperature Monitoring During Cardiopulmonary Bypass-Do We Undercool or Overheat the Brain?

Objective: Brain cooling is an essential component of aortic surgery requiring circulatory arrest and inadequate cooling may lead to brain injury. Similarly, brain hyperthermia during the rewarming phase of cardiopulmonary bypass may also lead to neurological injury. Conventional temperature monitoring sites may not reflect the core brain temperature (T°). We compared jugular bulb venous temperatures…

Differential Brain and Body Temperature During Cardiopulmonary Bypass-A Randomised Clinical Study

Differential Brain and Body Temperature During Cardiopulmonary Bypass-A Randomised Clinical Study

Objective: Maintenance of normothermia during cardiopulmonary bypass (CPB) may have advantages over hypothermia but there is a potential increased hazard of neurological injury. A novel aortic cannula (CobraTM catheter, Cardeon® Corp., Cupertino, CA, USA) which compartmentalises the aorta may allow simultaneous brain cooling during maintained corporeal normothermia. We investigated the thermal efficacy of this technique.…

Platelet-Derived Growth Factors for Wound Healing Billing Codes

Platelet-Derived Growth Factors for Wound Healing Billing Codes

Platelet Gel Billing Codes