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Tranexamic Acid X Approtinin on Blood Loss After CPB

Tranexamic Acid X Approtinin on Blood Loss After CPB

Introduction: Aprotinin (AP) reduces blood loss and transfusions after cardiopulmonary bypass (CPB), but may sensitise patients and is expensive. Tranexamic acid (TA) has less side-effects, but data regarding its efficacy are controversial. The aim of our prospective, randomised, double-blind study was to compare the impact of AP vs. TA on drainage blood loss and transfusion…

Variability of Plasma Aprotinin Concentrations in Pediatric Patients Undergoing Cardiac Surgery

Variability of Plasma Aprotinin Concentrations in Pediatric Patients Undergoing Cardiac Surgery

OBJECTIVES: Infants and children undergoing cardiopulmonary bypass for repair of congenital heart defects are at substantial risk for excessive bleeding, contributing greatly to morbidity and mortality. Aprotinin significantly reduces bleeding and transfusion requirements in adults but is of indeterminate value for pediatric patients. The aim of this study was to determine plasma aprotinin concentrations in…

Reducing Cardiovascular Risk Factors With Medication Has Benefits In Type 2 Diabetes

Reducing Cardiovascular Risk Factors With Medication Has Benefits In Type 2 Diabetes

Lowering cholesterol and blood pressure with medication has cardiovascular benefits for patients with type 2 diabetes mellitus. “Cardiovascular complications account for over 50 percent of mortality among patients with type 2 diabetes,” according to investigators from the University of Chicago, Illinois, and Massachusetts General Hospital in Boston, United States. The cardiovascular benefits of controlling risk…

Modified Ultrafiltration in Surgical Correction of Congenital Heart Disease with Cardiopulmonary Bypass

Modified Ultrafiltration in Surgical Correction of Congenital Heart Disease with Cardiopulmonary Bypass

The surgical correction of congenital heart disease using haemodilution and hypothermia with cardiopulmonary bypass (CPB) may expose patients to tissue ischaemia and initiate a systemic inflammatory response, increasing the total body water and inducing impairment, especially of heart, lung and brain function. It is possible to use ultrafiltration during CPB in the rewarming phase to…

Incidence of UTI High in Patients With Acute Coronary Syndromes

Incidence of UTI High in Patients With Acute Coronary Syndromes

NEW ORLEANS (Reuters Health) – Patients with unstable coronary syndromes are three times more likely to have urinary tract infections (UTIs) than other cardiac patients and the condition may be a trigger for myocardial infarction. At this year’s American College of Cardiology’s Annual Scientific Session 2004, Dr. John B. Sims of the University of Texas…

Vacuum-Assisted Venous Return Reduces Blood Usage

Vacuum-Assisted Venous Return Reduces Blood Usage

Objective: To determine whether vacuum-assisted venous return has clinical advantages over conventional gravity drainage apart from allowing the use of smaller cannulas and shorter tubing. Methods: A total of 150 valve operations were performed at our institution between February and July 1999 using vacuum-assisted venous return with small venous cannulas connected to short tubing. These…

Experimental Device Developed By Percutaneous Valve Technologies May Provide Alternative to Open Heart Surgery

Experimental Device Developed By Percutaneous Valve Technologies May Provide Alternative to Open Heart Surgery

Percutaneous Valve Technologies, Inc. (PVT) — a privately held medical technology company engaged in the development of a breakthrough device for the treatment of aortic stenosis — announced today that its less invasive aortic valve procedure was performed in a cardiac catheterization laboratory, for the first time, avoiding open-heart surgery to treat senile aortic stenosis,…

Surgery For Prosthetic Valve Obstruction May Currently Be Safest, Most Effective Treatment

Surgery For Prosthetic Valve Obstruction May Currently Be Safest, Most Effective Treatment

Early operation is appears effective and safe for most cases of prosthetic heart valve obstruction (PHVO), especially in patients in stable preoperative haemodynamic condition, according to a French study. Valve obstruction due to prosthetic thrombosis is one of the most serious complications associated with mechanical prosthetic valves. Surgery is usually the favoured treatment, although reported…

VEGF Gene Therapy for Heart Failure Reaching Phase III Trials

VEGF Gene Therapy for Heart Failure Reaching Phase III Trials

Gene therapy, using Vascular Endothelial Growth Factor 121 (AdVEGF121, Biobypass, GenVec, Gaithersburg, MD), effectively induces regrowth of blood vessels and improves exercise tolerance in patients with end-stage heart disease who are not candidates for surgery, researchers told attendees of the American Heart Association’s Scientific Sessions 2002 on Wednesday. Dr. Duncan John Stewart, of St. Michael’s…

Shortened Anticoagulation Course May Be Effective For Deep Vein Thrombosis

Shortened Anticoagulation Course May Be Effective For Deep Vein Thrombosis

A shortened course of warfarin anticoagulation therapy proved effective in treating deep vein thrombosis following total hip and knee arthroplasty. Canadian investigators enrolled 11 patients with deep vein thrombosis after hip or knee surgery at Kingston General Hospital in Ontario. Patients with chronic predisposing factors for thromboembolic disease, revision arthroplasty or previous deep vein thrombosis…

Diverse Causes of Prolonged Mechanical Ventilation Following CABG

Diverse Causes of Prolonged Mechanical Ventilation Following CABG

Prolonged mechanical ventilation (PMV) arises from diverse causes that vary over time and in their impact on ventilation duration following coronary artery bypass grafting (CABG). Researchers from the Physician Research Network, Methodist Healthcare University Hospital, Memphis, Tennessee, United States, enrolled 400 patients undergoing CABG. Using their standardized post-operative respiratory protocol, 41.8 percent of patients could…

Ventricular-Assist Devices Help Patients Wait for Cardiac Transplantation at Hom

Ventricular-Assist Devices Help Patients Wait for Cardiac Transplantation at Hom

Patients who need ventricular assist devices (VAD) while waiting for a heart transplant can leave the hospital and go home without increasing their mortality risk. Researchers in Germany and in the United States found that patients who were sent home wearing the devices may have done better than the patients who stayed in the hospital.…

Ventricular Assistance Device May Prevent Complications During Angioplasty

Ventricular Assistance Device May Prevent Complications During Angioplasty

The Tandem Heart percutaneous left ventricular assist device (pVAD) (Cardiac Assist Technologies, Inc., Ithaca, New York) may reduce complications associated with high-risk percutaneous coronary intervention (PCI), physicians in The Netherlands report. “The increase in safety provided by the circulatory bypass may potentially allow the treatment of patients at an extremely elevated risk, thereby eventually broadening…

Platelet Storage Solution Improves the in Vitro Function of Preserved Platelet Concentrate

Platelet Storage Solution Improves the in Vitro Function of Preserved Platelet Concentrate

BACKGROUND: Stored platelets develop biochemical lesions, manifest as depressed haemostatic function, clot retraction and wound healing. ViaCyte trade mark, a proprietary experimental preservative solution (comprising D-ribose, D-glucose, Hanks solution, Hepes solution, bovine serum albumin, tic anticoagulant peptide and sterile water), was tested in comparison with the presently accepted storage solution, citrate-dextrose-phosphate-plasma (CDP-P), to evaluate its…

Deciphering Viagra’s Heart Benefit

Deciphering Viagra’s Heart Benefit

FRIDAY, March 21 (HealthScoutNews) — The impotence drug Viagra appears to help protect the heart by stimulating the release of nitric oxide in cardiac cells, shielding a healthy heart against future damage. A Virginia Commonwealth University mouse study is the first to show that the drug, used to treat erectile dysfunction, produces therapeutic levels of…

Perfusion Community Sustains Great Loss in the Death of Viktor Magnusson

Perfusion Community Sustains Great Loss in the Death of Viktor Magnusson

The perfusion community has sustained a great loss. Viktor Magnusson, Chief Perfusionist in Reykjavik, Iceland, died Wednesday August, 30th . Viktor’s background was in the biomedical engineering field. He received his perfusion training in Uppsala, Sweden. In 1986 he moved to Iceland to help start the first and only open heart surgery program in Iceland…

Vitamin C Helps Stem Cells Become Heart Cells

Vitamin C Helps Stem Cells Become Heart Cells

By Jacqueline Stenson NEW YORK (Reuters Health) – In a finding that could aid the development of new heart failure treatments, scientists have observed that vitamin C prompts mouse embryonic stem cells to transform into beating heart muscle cells. A big hope is that doctors will one day have an ample supply of healthy human…

Weaning of Rotary Blood Pump Recipients After Myocardial Recovery: A Computer Study of Changes in Cardiac Energetics

Weaning of Rotary Blood Pump Recipients After Myocardial Recovery: A Computer Study of Changes in Cardiac Energetics

BACKGROUND: Weaning of patients from mechanical cardiac support after myocardial recovery has always involved multiple, interacting factors, particularly the training of the myocardium during reduction of pump flow. Rotary pumps offer training advantages when support flow is reduced, even to nearly zero. We report a computer analysis that evaluates the work required of the heart…

What is Perfusion? A Summary of the Different Types of Perfusion

What is Perfusion? A Summary of the Different Types of Perfusion

The term “perfusion” is derived from the French verb ‘perfuse’ meaning to ‘pour over or through’. Perfusionists employ artificial blood pumps to propel open-heart surgery patients’ blood through their body tissue, replacing the function of the heart while the cardiac surgeon operates. When a patient’s blood is continuously removed and returned through plastic tubing to…

Women Fare Worse Than Men During Coronary Artery Bypass Graft

Women Fare Worse Than Men During Coronary Artery Bypass Graft

Women who undergo coronary artery bypass graft surgery fare worse than men and are likely to be sicker when they have the surgery. Dr. Scott Woods of Bethesda Family Practice in Cincinnati, Ohio, and colleagues analyzed data from 1,742 men and 3,582 women and compared outcomes of male and female patients undergoing coronary artery bypass…

Wound Closure Technique Affects Postoperative Infection Rate

Wound Closure Technique Affects Postoperative Infection Rate

Percutaneous suturing results in fewer superficial wound infections than does intracutaneous suturing after open-heart surgery, according to results of a randomized study comparing the two techniques. “Intracutaneous suture technique has been our standard method for closing sternal wounds in cardiac surgery, mainly for cosmetic reasons,” Dr. Ivar Risnes and fellow cardiac surgeons from Rikshospitalet in…

Wound Healing Types and Stages: An Online Review

Wound Healing Types and Stages: An Online Review

Wound Healing Types: Primary Healing – Occurring when a wound is closed within a few hours of its creation. Wound edges are surgically or mechanically approximated, and collagen metabolism provides long-term strength. Delayed Primary Healing – Occurs when a poorly delineated wound is left open to protect against wound infection. The open wound allows for…

X Technologies Wins U.S. Nod for Heart Device, Clearing the Way for Acquisition by Guidant

X Technologies Wins U.S. Nod for Heart Device, Clearing the Way for Acquisition by Guidant

NEW YORK (Reuters Health) – Privately held X Technologies Inc. has won U.S. marketing clearance for a new device, fulfilling the conditions necessary for the firm to be acquired by cardiovascular device giant Guidant Corp. under a deal announced earlier this year. X Technologies’ device is used to help clear stents that clog after being…

Advocacy Group Sues FDA, Claims Agency is Withholding Risks of Xenotransplantation

Advocacy Group Sues FDA, Claims Agency is Withholding Risks of Xenotransplantation

WASHINGTON (Reuters Health) – The Campaign for Responsible Transplantation (CRT) on Monday has asked a federal district court to compel the US Food and Drug Administration (FDA) to release records detailing the potential risks of xenotransplantation that CRT officials claim the agency has but is concealing. “We want the court to rule that the FDA…

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