We are currently using the HTK solution as a primary cardioplegia at UPMC Presbyterian University Hospital in Pittsburgh, PA. I am doing some research into this as a cardioplegia agent as opposed to its intended use as an organ preservative. We typically give 2L initial dose; normally no further delivery is required. Blood gas analysis post cardioplegia reveals a serious drop in sodium (usually <126 mmol/L) accompanied by a drop in calcium (<0.96mmol/L).  While the HTK solution is designed to do this for organ preservation, I am curious as to its effects when introduced systemically through cardioplegia delivery (usually antegrade).  Any data concerning the use of HTK as a cardioplegia solution would be appreciated.