Bone Marrow Stem Cell Summary

Saturday, June 02, 2007 - Harvest Technologies


There's been a lot of interest in developing alternatives to autograft and the associated complications of iliac crest bone harvesting. One emerging alternative is to obtain the rich source of stem cells and proteins found in autograft without surgically harvesting the bone.

The bone marrow cavity in the hip contains a source of multi-potent stem cells, platelets, growth factors, adhesion molecules, and other proteins responsible for tissue repair and regeneration. Through simple aspiration, a physician can obtain all of these cells from the bone marrow.

Concentrated bone marrow contains enhanced levels of:

Bone Marrow-Mesenchemyl Stem (BM-MS) Cells for bone formation

  • BM-MS cells decrease with age
  • Concentrating mimics the cell load and healing potential of young patients
  • Convert directly to bone and work in areas of hypoxia
Endothelial Stem Cells for supporting vasculature
  • Healing is impaired until the vasculature is restored
  • Converts directly to vasculature
  • Stimulate BM-MS cells
  • Stimulated by and work in areas of hypoxia
Hematopoietic Stem Cells for supplying nutrients
  • Form blood cells
  • Cell-to-cell contact with BM-MS cells stimulate osteogenesis
Platelets to modulate the regeneration process
  • Recruit bone marrow progenitor cells to foci of injury
  • Provide adhesion sites for stem cells
  • Platelet-fibrin clot/network provides migration highway at the site of injury
Adhesion Molecules
  • Mediate cell-to-cell adhesion
  • Maintenance of tissue integration, wound healing, and cellular migration


• Harvest Technologies


        

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